purpose: to report the first case of concomitant optic nerve transection and chorioretinitis sclopetaria patient and findings: a 12-year-old boy with history of bb gun injury to his right eye was referred for loss of vision 8 months after the accident. visual acuity in the right eye was counting fingers at one meter with 3+ rapd. on slit lamp examination, right eye seemed normal except 1+ anter...

a 15- year-old boy with history of bb gun injury to his left eye was referred to our center. his visual acuity was no light perception in the left eye. ocular findings were severe proptosis, conjunctival injection, and conjunctival vascular tortuosity. fundus examination revealed an extensive inferior chorioretinal scar compatible with chorioretinitis sclopetaria. a distinct bruit was detected ...

Previous studies have shown that the secondary degeneration of retinal ganglion cells (RGCs) occurs commonly in glaucoma. Partial optic nerve transection is considered a useful and reproducible model. Compared with other optic nerve injury models used commonly for assessing secondary degeneration, e.g. complete optic nerve transection and optic nerve crush models, the partial optic nerve transe...

Secondary degeneration occurs commonly in the central nervous system after traumatic injuries and following acute and chronic diseases, including glaucoma. A constellation of mechanisms have been shown to be associated with secondary degeneration including apoptosis, necrosis, autophagy, oxidative stress, excitotoxicity, derangements in ionic homeostasis and calcium influx. Glial cells, such as...

BACKGROUND Optic nerve transection and chorioretinitis sclopetaria may occur following blunt ocular trauma. However, simultaneous occurrence has not yet been reported. We report the first case of concomitant optic nerve transection and chorioretinitis sclopetaria. CASE PRESENTATION A 12-year-old boy with history of BB gun injury to his right eye was referred for loss of vision. His visual acu...

We report that the most common retinal ganglion cell type that remains after optic nerve transection is the M1 melanopsin ganglion cell. M1 ganglion cells are members of the intrinsically photosensitive retinal ganglion cell population that mediates non-image-forming vision, comprising ∼2.5% of all ganglion cells in the rat retina. In the present study, M1 ganglion cells comprised 1.7±1%, 28±14...

Studies have demonstrated that optic nerve transection results in apoptotic cell death of retinal ganglion cells (RGCs) and neurons within lateral geniculate nucleus (LGN). Heat shock protein (Hsp) 70 was reported to be involved in protecting cells from injury under various pathological conditions in vivo and in vitro. To determine the involvement of Hsp70 in protecting neurons within LGN again...

PURPOSE To isolate the rat Myoc/Tigr gene and investigate changes in its expression pattern in normal eyes and in eyes with either pressure-induced optic nerve damage or optic nerve transection. METHODS Expression pattern of the rat Myoc/Tigr gene was investigated by Northern blot hybridization. Optic nerve damage and death of ganglion cells in the retina were induced unilaterally, by injecti...

I n a prior communication we demonstrated that transection of the optic nerve of the cat with consequent retrograde neuronal degeneration did not lead to alteration of the ipsilateral retinal vasculature. We interpreted this to mean that retinal neuronal degeneration does not, of itself, cause an associated vascular degeneration. In the present study the vasculature of the optic disc region of ...

We have shown previously that the A2B5 monoclonal antibody distinguishes two types of glial fibrillary acidic protein-containing astrocytes in semithin frozen sections of adult rat optic nerve: A2B5- (type-1) astrocytes are found mainly at the periphery of the nerve, where they form the glial limiting membrane, while A2B5+ (type-2) astrocytes are found mainly in the interior of the nerve and co...