The p53 protein function is essential for the maintenance of the nontumorigenic cell phenotype. Pancreatic tumor cells show a very high frequency of p53 mutation. To determine if restoration of wild type p53 function can be used to eliminate the tumorigenic phenotype in these cells, pancreatic tumor cell lines, PANC-1 and HTB80, differing in p53 status were stably transfected with exogenous wil...

Objective(s): Diabetes is a metabolic disease with an increasing prevalence for which finding new and efficient therapeutic approaches has always been a challenge. Preserving integrity and functionality of pancreatic β-cells as the only source of insulin in the body is such a case. To achieve this goal different cellular targets have been proposed among which pancreatic estrogen receptors have ...

samples of formalin fixed gastrointestinal organs of three month ostrich chicks were submitted to the department of pathology, razi vaccine and serum research institute. histologically hepatitis and pancreatitis with large eosinophilic intra nuclear inclusion bodies were prominent in hepatic and pancreatic cells. these inclusions were suspected as adenovirus inclusion body hepatitis (ibh) in va...

background: pancreatitis is a serious complication of endoscopic retrograde cholangiopancreatography (ercp) and may cause significant morbidity and even death. there is no effective prophylactic intervention for patients with average risk yet. this study aims to investigate preventive effect of aggressive hydration for post-ercp pancreatitis. materials and methods: in a double-blind controlled ...

Schwannomas may occur anywhere in the soft tissues or viscera, but do not commonly involve the pancreas and retroperitoneum. We present a case of benign pancreatic schwannoma which clinically simulated a malignant neoplastic process.

conclusions there was a significant correlation between elevated lipase levels and the incidence of multiple organ failure. moreover, no significant association was found between the elevated amylase levels and organ failure. however, on admission, measurement of these enzymes coupled with routine laboratory investigations can be a powerful tool in the early detection of patients progressing to...