INTRODUCTION We present 3 patients with parathyroid carcinoma and describe their presentations, clinical profiles, and management. MATERIALS AND METHODS A case series review of medical records. RESULTS Two women and 1 man (age range, 32 to 57 years) had parathyroid cancer and primary hyperparathyroidism (PHPT). One patient presented with osteitis fibrosa, 1 with renal stone and a neck mass,...

OBJECTIVE To determine the potential role of intraoperative carbon nanoparticles (CN) injections for identification and preservation of parathyroid glands, thereby reducing the postoperative hypocalcaemia. METHODS 100 patients with thyroid cancer who underwent total thyroidectomy and central compartment node dissection (CCND) were randomly assigned to receive intraoperative injection of (CN) ...

Objective(s): In this study, we aimed to analyze the relationship between the diagnostic ability of fused single photon emission computed tomography/computed tomography (SPECT/CT) images in localization of parathyroid lesions and the size of adenomas or hyperplastic glands. Methods: Five patients with primary hyperparathyroidism (PHPT) and 4 patients with secondary hyperparathyroidism (SHPT) we...

  Introduction: Radio-guided parathyroid surgery along with other minimally invasive surgeries constitutes the main surgical treatment procedures for different kinds of hyperparathyroidism.  In this article we have reported our experience of radio-guided parathyroid surgery using Tc-99m sestamibi. Methods: Ten patients with hyperparathyroidism included in our study. ...

The majority of parathyroid tumors are benign, and parathyroid carcinomas represent a diagnostic challenge with limited treatment options. Multiple endocrine neoplasia type 1 gene and cell division cycle 73 (CDC73) are major genes in parathyroid adenomas and carcinomas respectively. However, a large group of parathyroid tumors remain without defined genetic background. Telomeres are chromosome-...

A rare scintigraphic phenomenon of “superscan” is considered – an abnormally high diffuse accumulation osteotropic radiopharmaceutical by all skeletal parts in combination with the absence kidney and tissue background imaging. This feature reflects a generalized bone system lesion metastatic, metabolic or hematological nature. We present clinical observation retrospective assessment data obtain...

Parathyroid carcinoma (PC) is a very rare endocrine cancer with aggressive behavior, high metastatic potential, and poor prognosis. Surgical resection of affected gland(s) other involved structures the elective therapy. Pre-operative intra-operative differential diagnosis benign parathyroid adenoma remains challenge. The lack clear pre-operative does not allow one, in many cases, to choose corr...

Abstract Background A rare cause of primary hyperparathyroidism (PHPT) is a parathyroid carcinoma. Hypercalcemia with an elevated hormone (PTH) level seen in recurrent and metastasis disease cases often refractory to medical therapy, thus surgical resection recommended when possible. We performed debulking surgery for pleural dissemination cancer improvement symptoms patient hypercalcemia. Case...

BACKGROUND Parathyroid carcinoma is a rare malignancy, with an incidence of 0.5 to 4% of all cases of primary hyperparathyroidism. Surgery is the only curative treatment. CASE PRESENTATION We report the case of a 66-year-old man referred for a large suspicious substernal goitre associated with severe hypercalcemia due to hyperparathyroidism. After normalization of serum calcium levels, patien...

Localization of 99mTc- hexakis-2-methoxyisobutylisonitrile (99mTc-MIBI) by parathyroid adenomas is well known, and this warrants MIBI scan to evaluate suspected parathyroid adenoma in primary hyperparathyroidism. Typically, the radionuclide concentrates in both the thyroid gland and parathyroid adenoma in early images, and later on delayed images washes out slowly from the...