Background: Patients with symptomatic malignant pleural effusion (MPE) may gain profit from pleurodesis for relief of dyspnea and in preventing the accumulation of fluid or air in the pleural space. Pleurodesis methods are palliative and regard the patient's symptoms and underlying disease condition that are different. The purpose of this study was to assess the efficacy of bleomycin in the tre...

Background: Some authors detected significantly higher IL-18 levels in serum, peritoneal, and pleural fluids of patients with severe OHSS as compared with control groups and suggest a role of IL- 18 as a marker of OHSS. Lower levels of IL-18 have been found to characterize unexplained infertility. In this study, we analyzed the importance of IL-18 levels in serum and follicle fluid in response ...

multiple myeloma (mm) characterized by proliferation of plasma cells in bone marrow and production of monoclonal immunoglobulin's. recently, arsenic trioxide (ato), has been considered for treatment refractory mm. we assessed the safety and efficacy of ato for patients with refractory mm. a phase 2, study of arsenic trioxide was conducted in 12 mm patients, whose refractory to two standard ther...

conclusions family history as well as baseline bilirubin, ast and hbv dna levels can predict early virological response. the model provides a better tool for response prediction based on the four prognostic factors. results negative family history of hbv infection (p = 0.000235), baseline higher serum tbil (p = 0.038714) and ast (p = 0.020684) concentrations, and lower level of hbv-dna (p = 0.0...

background : the present study aimed to compare the rates of complete clinical and pathologic response to docetaxel, doxorubicin and cyclophosphamide (tac) vs. 5-fluorouracil, doxorubicin and cyclophosphamide (fac) as neoadjuvant chemotherapy in women with locally advanced breast cancer. methods : one hundred women with pathologically confirmed newly diagnosed locally advanced (t3-t4 or n2-n3) ...

metabolic syndrome and its pathological sequel, type 2 diabetes are considered as important global health problems. metformin is the most common drug prescribed for patients with this disorder. consequently, understanding the genetic pathways involved in pharmacokinetics and pharmacodynamics of this drug can have a considerable effect on the personalized treatment of type 2 diabetes. in this st...

treatment of bone metastases comprises over 10% of the workload of a radiation-oncology center. bone metastases produce severe pain and immobility, necessitate narcotic use, and reduce the quality of life. a good palliative treatment must be complete, free from side effects and fast; thus we decided to evaluate strontium-89 (89sr) effectivity for palliation of breast and prostate cancer bone me...