This commentary on the Editorial ‘The politics and analytics of health policy’ by Professor Calum Paton focuses on two issues. First, it points to the unclear links between ideas, ideology, values, and discourse and policy, and warns that discourse is often a poor guide to enacted policy. Second, it suggests that realism, particularly ‘programme theory’ are useful tools for health policy analys...

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The article by Paton and colleagues on the use of psychotropic medication in patients with emotionally unstable personality disorder (EUPD) in the current issue of JCP is an important article. Making the assumption that EUPD as defined by ICD-10 (F60.3) is reasonably equivalent to borderline personality disorder (BPD) as defined in the United States by DSM, we are provided some insight into how...

This is the peer reviewed version of the following article: Conway, M. E., Hull, J., El Hindy, M., Taylor, S., El Amraoui, F., Paton?Thomas, C., White, P., Williams, H., Haynes, H., Bertoni, A., Radlwimmer, B., Hutson, S. and Kurian, K. (2016) Decreased expression of the mitochondrial bcat protein correlates with improved patient survival in idh?wt gliomas. Brain Pathology, which has been publi...

T H E increasing understanding of the mechanism of action of the muscle relaxants has led to a high degree of safety in their use. Nevertheless, the occasional patient is still encountered in whom the response to the drug is greater than anticipated. There are already a number of reports in the literature outlining the almost unlimited number of causes for this prolonged response (Paton, 1958; ...

Hexan-1 I: 6-bi(-trimethylammonium bromide) (C6) has been extensively studied about its pharmacological properties such as ganglionic blockade by Barlow, Ing, (1) (1948), Paton, Zaimis (2) (1951) and Wien, Mason (3) (1951) but less known about the mode of action in the biochemical sense. On the other hand it has been well known that nicotine action is antagonized by C6. The study of the effect ...

A gene from Streptococcus pneumoniae was cloned in lambda EMBL301 and then expressed in Escherichia coli, which cleaved the fluorogenic neuraminidase substrate 2'-(4-methylumbelliferyl)-alpha-d-N-acetylneuraminic acid. The cloned gene therefore encodes an enzyme with neuraminidase activity. On the basis of restriction mapping and DNA hybridization studies, this gene could be distinguished from ...

We demonstrate that a Hermitian matrix model can be derived from level truncated open string field theory with Chan-Paton factors. The Hermitian matrix is coupled with a scalar and U(N) vectors which are responsible for the D-brane at the tachyon vacuum. Effective potential for the scalar is evaluated both for finite and large N. Increase of potential height is observed in both cases. The large...