ELAV is a gene-specific regulator of alternative pre-mRNA processing in Drosophila neurons. Since ELAV/Hu proteins preferentially bind to AU-rich regions that are generally abundant in introns and untranslated regions, it has not been clear how gene specificity is achieved. Here we used a combination of in vitro biochemical experiments together with phylogenetic comparisons and in vivo analysis...

Amelogenesis imperfecta is a group of disorders causing abnormalities in enamel formation in various phenotypes. Many mutations in the FAM83H gene have been identified to result in autosomal dominant hypocalcified amelogenesis imperfecta in different populations. However, the structure and function of FAM83H and its pathological mechanism have yet to be further explored. Evolutionary analysis i...

Hepatitis C virus (HCV) is a worldwide health problem with high morbidity and mortality. HCV polymerase is an attractive target for the development of antiviral strategies. The aim of the present study was to report the sequence variation in the HCV NS5B gene from genotype 3 patient samples. The gene was amplified, cloned and sequenced. A nucleotide and amino acid sequence comparison of conserv...

The lysin motif (LysM) domain is an ancient and ubiquitous protein module that binds peptidoglycan and structurally related molecules. A genomic survey in a large number of species spanning all kingdoms reveals that the combination of LysM and receptor kinase domains is present exclusively in plants. However, the particular biological functions and molecular evolution of this gene family remain...

SWEETs (sugars will eventually be exported transporters) have various physiological and biochemical roles in plant growth, including pollen development, seed nourishment, nectar secretion, longer-distance sugar transportation. The SWEET genes were identified species, but they not yet been thoroughly characterized. Here, we discovered 21 putative from the Eriobotrya japonica Lindl. genome. For f...

The TRP channel superfamily was widely found in multiple species. They were involved many extrasensory perceptions and important for adapting to the environment. migratory locust one of worldwide agricultural pests due huge damage. In this study, we identified 13 genes genome. number LmTRP consistent with most insects. phylogenetic tree showed that could be divided into seven subfamilies. conse...

Most cultivated lands are suffering from soil salinization, which is a global problem affecting agricultural development and economy. High NaCl concentrations in the result accumulation of toxic Cl? Na+ plants. Na+/H+ antiporter (NHX) can regulate compartmentalization or efflux to reduce toxicity. This study aims identify NHX genes pomegranate (Punica granatum L.) genome sequences investigate t...