In previous studies, mebudipine, a dihydropyridine calcium channel blocker, showed a considerable potential to be used in cardiovascular diseases. The aim of the current study was to develop a valid method using reversed-phase high performance liquid chromatography coupled with electrospray ionization mass spectrometry to assay mebudipine in the human plasma. Separation was achieved on a Zorbax...

In this study, a high-performance liquid chromatographic method (HPLC) and UV spectrophotometric method were developed, validated and applied for the determination of theophylline in biological fluids. Liquid- liquid extraction is performed for isolation of the drug and elimination of plasma and saliva interferences. Urine samples were applied without any extraction. The chromatographic separat...

In this study, a high-performance liquid chromatographic method (HPLC) and UV spectrophotometric method were developed, validated and applied for the determination of theophylline in biological fluids. Liquid- liquid extraction is performed for isolation of the drug and elimination of plasma and saliva interferences. Urine samples were applied without any extraction. The chromatographic separat...

We monitored the behavior of residual myeloma plasma cells in patients with multiple myeloma after high-dose therapy and autologous or allogeneic transplantation using 3 methods of a flow cytometric technique using 4-color staining, immunofixation, and polymerase chain reaction approaches. We analyzed 17 cases by a relatively simple flow cytometric technique using CD38/CD45/CD19/CD56. Detectabl...

Abstract Some plasma propulsion concepts rely on a strong magnetic field to guide the plasma flow through the thruster nozzle. The question then arises of how the magnetically confined plasma can detach from the spacecraft. This work presents an MHD detachment scenario in which the plasma flow stretches the magnetic field lines to infinity. Detachment takes place after the energy density of the...

Increasing evidence that the edge plasma plays a crucial role in global tokamak continement motivates this study of two-dimensional (2-D) (0,~) computational models of fluid transport in the edge plasma region. Fluid plasma equations, boundary conditions, and a coupled neutral-plasma model are developed assuming toroidal symmetry. A plasma potential equation~is presented for consistent drift fl...

A relatively simple design of a segmented flow meter is presented for measuring in situ plasma velocities and other space parameters. The response the to environment simulated conditions representative ionosphere at mid low latitudes using Particle cell code. synthetic data set consisting ion currents collected by several segments meter, physical parameters which they were calculated, then used...