cumulating evidence points to a key role for cd8+ t cells in the pathogenesis of multiple sclerosis.cd8 expression level was believed to be present constantly on the surface of human peripheral blood t cells. however, it was shown that peripheral blood lymphocytes may be divided by the level of cd8 expression, into cd8+high and cd8+low t cells. now it is well established that the cd8low populat...

conclusions the cd4+ and cd8+ tcr vβ gene families undergo clonal expansion in cshb patients, and cd8+ t cells play a major role in the pathogenesis of cshb. moreover, the conserved motifs and limited use of joining region genes observed in the cshb patients of this cohort indicated that similar antigenic epitopes are recognized. results the number of oligoclonal or monoclonal expansion tcr vβ ...