نتایج جستجو برای: premature aging
تعداد نتایج: 161300 فیلتر نتایج به سال:
Mitochondrial DNA (mtDNA) mutator mice are proposed to express premature aging phenotypes including kyphosis and hair loss (alopecia) due to their carrying a nuclear-encoded mtDNA polymerase with a defective proofreading function, which causes accelerated accumulation of random mutations in mtDNA, resulting in expression of respiration defects. On the contrary, transmitochondrial mito-miceΔ car...
Mutations in the gene Klotho lead to premature ageing in mice. Recent work on human genetic variation has identified an association between a particular allele of Klotho and human lifespan. A harbinger of things to come, this work illustrates the power and growth potential for association studies of human ageing.
Foxo transcription factors have been implicated in diverse biological processes, including metabolism, cellular stress responses, and aging. Here, we show that Foxo3a-/- female mice exhibit a distinctive ovarian phenotype of global follicular activation leading to oocyte death, early depletion of functional ovarian follicles, and secondary infertility. Foxo3a thus functions at the earliest stag...
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