a female one month old with features supporting a diagnosis of neonatal progeroid syndrome(wrs)  presented to our neonatology section of gb pant children hospital srinagar .she had prenatal and post natal growth failure, generalized lipotrophy, triangular face, psedohydrocephalous, sparse scalp hair and eye brows, prominent scalp veins and greatly widened anterior fontenella.

skin aging is a continuous process that exhibits fine and deep wrinkles, thin and transparent skin, loss of underlying fat, dry skin and itch, following decreased collagen and elastin  synthesis. both extrinsic and intrinsic agents are considered in the pathogenesis on skin aging. extrinsic factors such as sun exposure, windy and dry weather, nutrition, and lifestyle may induce premature aging,...

Hutchinson–Gilford Progeria Syndrome, Werner syndrome, and Cockayne syndrome are three genetic disorders, in which the children have premature aging features. To understand the phenomena of premature aging, the similarity of aging features in the syndromes to that in normal aging is investigated. Although these syndromes have different genetic backgrounds, the patients all have abnormal structu...

DNA methylation gradiently changes with age and is likely to be involved in aging-related processes with subsequent phenotype changes and increased susceptibility to certain diseases. The Hutchinson-Gilford Progeria (HGP) and Werner Syndrome (WS) are two premature aging diseases showing features of common natural aging early in life. Mutations in the LMNA and WRN genes were associated to diseas...

It is well documented that life expectancy in developed countries at birth is going to increase from the 20th century. However, regrettably, a potential decline in life expectancy has been proposed for these nations in the 21st century due to a rapid upsurge in the prevalence of fatal degenerative diseases like cardiovascular diseases (CVD), cancer and diabetes. Collectively, these three diseas...

Aging is a process experienced by the human body where function of parts becomes reduced, for example, skin getting thinner and then wrinkles appear. Premature aging occurs due to photoanging UV radiation some bad living habits. In reducing signs on skin, antioxidants are needed protect from damage caused oxidation so that it can prevent premature aging. Antioxidants be enzymes (eg superoxide o...

Mitochondria play a critical role in the life of the cell as they control their metabolic rate, energy production and cell death. Mitochondria have long been appreciated as causative to aging. The age-associated respiratory chain deficiency is typically unevenly distributed and affects only a subset of cells in various human tissues, such as heart, skeletal muscle, colonic crypts and neurons. S...