OBJECTIVE A genetic risk score (GRS) for coronary artery disease has recently been shown to be independent of family history (FHx) in predicting future cardiovascular events. We sought to determine whether the presence of these risk factors, either individually or together, was associated with a higher burden of angiographic coronary artery disease. APPROACH AND RESULTS We included 763 patien...

background: data on premature coronary artery disease (cad) are scarce. the tehran heart center's premature coronary atherosclerosis cohort study (thc-pac) is the first study of its kind in the middle east to assess major adverse cardiac events (mace) in young cad patients. methods: the cohort consists of cad patients, males ≤ 45 years old and females ≤ 55 years old. the participants are reside...

familial hypercholesterolemia (fh) is a hereditary dislipidemia. patients present with extremely high level of low-density lipoprotein cholesterol (ldl-c), which is due to mutation in the gene of ldl receptor. homozygous patients (hofh) whose incidence is 1 in 1.000.000 are at high risk of premature aortic valve stenosis, and coronary artery atherosclerosis. in homozygous individuals cardiovasc...

severe coronary artery disease often coexists with peripheral vascular atherosclerosis. the assessment of the supra-aortic circulation is, therefore, of clinical relevance. we herein describe a case of coronary artery disease treated with surgical revascularization using the internal mammary artery and thereafter the progressive atherosclerotic disease of the native coronary arteries as well as...

background: investigators frequently encounter continuous outcomes with plenty of values clumped at zero called semi-continuous outcomes. the gensini score, one of the most widely used scoring systems for expressing coronary angiographic results, is of this type. the aim of this study was to apply two statistical approaches based on the categorization and original scale of the gensini score to ...

this study was performed to assess the clopidogrel activity in inhibition of platelet aggregation in suspected angina patients on a daily dosag of 75 mg of clopidogrel for at least 7 days. this clinical trial was conducted in the outpatients department of cardiology, post graduate medical institute, lady reading hospital, peshawar from 15th october 2007 to 20th december 2007. we included 105 su...