TAYLOR, ROBERT E. Effect of procaine on electrical properties of squid axon membrane.Am. J.Physiol. 196(s) :1071--1078. 1g5g.Procaine (0.025-0.1%; pH 7.9) caused a reduction in the amount and rate of development of the early transient (sodium) and late steady state (potassium) currents which occur during a depolarizing voltage step applied to the excised, voltage clamped squid axon. Consistent ...

In studying "the inhibitory action of procaine upon the reflex-bradycardia*," it was found to be necessary to make more detailed observation on the changes in the heart rate after procaine itself. Krause(1) reported recently that novocaine injected intravenously on dogs usually produced an increase of heart rate with a rise of blood pressure which continued from 2 to 15 minutes. The author's re...

Stability or procaine and potassium salts of penicillin G in oleaginous Materials containing colloidal silica was studisd. The instability of penicillin G in these bases seeMed to be due pr!Marily to the surface acidity or the silica in conjunction with the ester constituents of oils. The stability or the peanut oil/silica/ penicillin G preparations could be !Mproved by reducing the surface aci...

Mouse fibroblast LM cells have been modified with respect to the content of polyunsaturated fatty acyl (PUFA) chains of the membrane phospholipids. The membranes of the modified cells were enriched in PUFA chains and were more fluid as compared to the normal cells, as judged by fluorescence polarization mea surements. The thermosensitivity of the PUFA-substituted cells was enhanced. Thermotoler...

The effects of tetrodotoxin, procaine, and manganese ions were examined on the Ca spike of the barnacle muscle fiber injected with Ca-binding agent as well as on the action potential of the ventricular muscle fiber of the frog heart. Although tetrodotoxin and procaine very effectively suppress the "Na spike" of other tissues, no suppressing effects are found on "Ca spike" of the barnacle fiber,...

The effects of i.v. and local anaesthetics on guineapig tracheal smooth muscle have been investigated in vitro. Diazepam, propanidid and ketamine induced relaxation and antagonized histamine-, acetylcholine-and potassium chloride-induced contractures in the tracheal smooth muscle. The relaxing effects of the anaesthetics were not affected by propranolol. Thiopentone, at concentrations which wou...

The introduction of procaine amide for the control of cardiac arrhythmias in man has been recent (Mark et al., 1950). There are relatively few reports at present concerned with it. Those published have dealt chiefly with the use of the preparations of the drug given by intravenous injection and have emphasized its value in arrhythmias of ventricular origin (Mark et al., 1950; Joseph et al., 195...

Accessible online at: www.karger.com/dig Having been trained in the German-speaking world of pancreatology, I was taught that the pain of patients with pancreatitis is special – special in that it responds well to intravenous procaine, a drug then commonly used as either a local anaesthetic or a cure for ventricular arrhythmias. Special also in that drugs generally used for a pain in other dise...

Cytotoxic effects of procaine, lignocaine and bupivacaine were investigated on cultures of Chinese hamster lung fibroblasts. Cell growth was inhibited over 24 h exposures with an ED50 of 0.17% for procaine, 0.07% for lignocaine and 0.02% for bupivacaine. Cell survival (measured as colony-forming ability) was reduced over 24 h exposure with an ED50 of 0.21% for procaine, 0.09% for lignocaine and...

an aqueous or oily suspension of procaine penicillin or of procaine penicillin in oil with 2 per cent. aluminium monostearate (PAM). Today 2 4 mega units is a not unusual dose. In Sheffield we have not yet arrived at this exalted twist of the spiral. In 1960 the routine dose was increased to 0-6 mega units of aqueous procaine penicillin, but with a relapse rate which is again rising it behoves ...