Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system characterized by demyelination and axonal degeneration. MS patients typically present with relapsing-remitting (RR) course, manifesting as sporadic attacks neurological symptoms including ataxia, fatigue, sensory impairment. While there are several effective disease-modifying therapies able to address relaps...

BACKGROUND Beta(2) adrenoreceptor expression on peripheral blood mononuclear cells is increased in progressive multiple sclerosis. This increase has been correlated with disease activity in relapsing-remitting multiple sclerosis. OBJECTIVE To determine the beta(2) adrenoreceptor expression in primary and secondary progressive multiple sclerosis in relation to findings on magnetic resonance im...

Mitoxantrone is the first drug approved for the treatment of secondary progressive multiple sclerosis (SPMS) in the United States. This assessment considers use of mitoxantrone in the treatment of MS. Mitoxantrone probably reduces the clinical attack rate and reduces attack-related MRI outcomes in patients with relapsing MS (Type B recommendation). Also, mitoxantrone may have a beneficial effec...

Tumour necrosis factor alpha gene (TNF-alpha)-376 polymorphism in Hungarian patients with primary progressive multiple sclerosis. APOE epsilon status in Hungarian patients with primary progressive multiple sclerosis. Validation of the Fatigue Impact Scale in Hungarian patients with multiple sclerosis. Qual Life Res. Factors influencing the health-related quality of life in Hungarian multiple sc...

Aim: Multiple sclerosis (MS) is one of the most common chronic progressive neurological diseases and is regarded as the non-traumatic cause of neurological disability in youth. The Multiple sclerosis patients need for family caregiver increasingly grows due to the progressive course of the disease, which worsens the symptoms over time. Family caregivers of this group of patients are subject to ...

how to cite this article: najafi mr, najafi ma, nasr z. diagnosis and management of multiple sclerosis in children. iran j child neurol. summer 2016; 10(3): 13-23. abstract growing evidence indicates the safety and well toleration of treatment by disease-modifying in children suffering multiple sclerosis (ms). the treatment is not straight forward in a great number of patients, thus patients wi...