There is currently a lack of evidence to suggest superior clinical efficacy of one oral proton pump inhibitor over any other. Proton pump inhibitors display similar doseresponse relationships with similar potencies and efficacies at the equivalent dose. The decision to select one proton pump inhibitor over another is likely to be based on the agents’ licensed indication, patient tolerability an...

Magnesium homeostasis is essential for many intracellular processes and depends on the balance of intestinal absorption and renal excretion. Hypomagnesaemia may arise from various disorders. We review the literature on hypomagnesaemia due to the use of proton pump inhibitors, as illustrated by a case of a 76-year-old woman with muscle cramps and lethargy caused by hypomagnesaemia and hypocalcae...

Recently, proton pump inhibitors (PPIs) have been widely used as the first-line treatment for acid-related diseases such as gastroesophageal reflux disease (GERD), gastric ulcers and duodenal ulcers. The number of PPI users has been increasing throughout the world. The suppression of gastric acid by the long-term use of PPIs is suggested to be associated with a number of disorders, including co...

Endoscopic submucosal dissection has made it possible to resect large lesions during a single operation. The present study was undertaken to compare the time taken for recovery from artificial ulcers after endoscopic submucosal dissection between an H(2) Receptor Antagonist treatment group and a Proton Pump Inhibitor treatment group, focusing on analysis of the time course of reduction rate in ...

AIM To perform a systematic review on the efficacy of intermittent and on-demand therapy with either histamine H2-receptor antagonists or proton pump inhibitors for patients with erosive oesophagitis or symptomatic heartburn. METHOD We conducted randomized-controlled trials of non-continuous therapy in gastro-oesophageal reflux disease patients. RESULTS Fourteen studies met inclusion criter...

herein, we report on a 24-year-old woman with a large well- marginated gastric mucosa-associated lymphoid tissue (malt) lymphoma. she presented with dysphagia and epigastric pain. in esophago­gastro­duodeno­scopy there was a huge bulging submucosal mass with normal appearing mucosa in the cardia in addition to a grade b gastro-esophageal reflux disease. she was treated with a proton pump inhibi...

The use of proton pump inhibitors in the elderly population may increase the risk of vitamin B12 deficiency, as gastric acid is needed for vitamin B12 absorption. It is unclear whether the same risk is present for non-elderly adults reporting chronic use of proton pump inhibitors. The aim of this study was to determine whether chronic use of proton pump inhibitors results in increased urinary m...

OBJECTIVE To perform a systematic literature review that evaluates the impact of proton pump inhibitor treatment of gastroesophageal reflux disease on sleep disturbance-related outcomes. DATA SOURCES PubMed, Web of Science, and Cochrane databases were searched from 1989 (when omeprazole became available) to present; additional references gleaned from citations. REVIEW METHODS The search str...