Remote ischemic conditioning (RIC) is the phenomenon whereby brief episodes of peripheral ischemia-reperfusion, typically applied to ≥1 limbs by inflation–deflation of a standard blood pressure cuff, increase the tolerance of the myocardium to a sustained ischemic episode. Compelling preclinical evidence of infarct size reduction with RIC, together with promising results from small, proof-of-co...

Ischemic heart disease is the leading cause of death and morbidity in the world, and ST-segment elevation myocardial infarction (STEMI) remains associated with a significant mortality rate and complications noted at 1-year follow-up, despite prompt coronary reperfusion achieved with either thrombolysis or primary percutaneous coronary intervention (PPCI). It is therefore clear that novel cardio...

aim and background: remote ischemic preconditioning introduces brief episodes of ischemia and reperfusion which reduces long term ischemia in orthopaedic surgery. the aim of this study was to evaluate hemodynamic and respiratory effects of remote ischemic preconditioning in lower extremity orthopaedic surgeries. methods: in this clinical trial 40 patients scheduled for lower extremity surgery w...

Introduction: Remote ischemic conditioning upregulates endogenous protective pathways in response to ischemia-reperfusion injury. This study tested the hypothesis that limb remote per-conditioning (RIPerC) exerts cardioprotective effects via renin-angiotensin system (RAS)/inducible nitric oxide synthase (iNOS)/apelin pathway. Methods: Renal injury (I/R) was induced by bilateral occlusion of ren...