common variable immunodeficiency (cvid) is a heterogeneous group of disorders characterized by hypogammaglobulinemia and an increased susceptibility to recurrent infections as well as autoimmunity and malignancies. idiopathic thrombocytopenic purpura (itp) and autoimmune hemolytic anemia (aiha) are two autoimmune disorders which may be seen in association with cvid. among 85 cvid patients, seve...

Mitochondrial respiratory chain disorders comprise a group of perhaps several hundred different genetic diseases. Each individual disorder is rare, but collectively they account for substantial use of health care resources. However, few accurate data on prevalence are available due to problems such as variation in clinical presentation, age of onset, referral practices and limitations of diagno...

Disorders in the fetoplacental complex of pregnant women with chronic respiratory diseases (CRD) is one actual problems modern obstetrics medical, economic and social aspects. Respiratory context disorders (FPC) may be a comorbid process, background to pathology pregnancy, or premorbid condition that contributes development placental dysfunction (PD) even initiates it; morphophysiological chang...

background: respiratory diseases cause a considerable amount of morbidity and mortality in the world. pulmonary function tests are important measures for the diagnosis and management of respiratory disorders. workers in tile and ceramic industry are exposed to high amounts of respiratory pollutants. objective: to identify the changes in spirometric parameters in a 2-year period among tile and c...

Tiglyglycine (TG), an intermediate product of the catabolism of isoleucine, is increased in the urine of patients with beta-ketothiolase deficiency or with disorders of propionate metabolism. It is also implicated as a useful diagnostic marker in disorders of the respiratory chain. We present a method for the synthesis of TG and tiglyl[13C, 15N]glycine and the development of a stable isotope di...