correspondence: Jeremy R DeGrado Department of Pharmacy, Brigham and Women’s hospital, 75 Francis st, Boston, MA 02115, UsA Tel +1 617 732 7677 Fax +1 617 566 2396 email [email protected] Purpose: Sedatives and analgesics are commonly used in mechanically ventilated patients in the intensive care unit. Sedation guidelines have been shown to improve sedation management as well as various pat...

Question: Does early provision of rehabilitation improve the likelihood of functional independence at discharge in ventilated, critically ill patients? Design: Randomised, controlled trial with concealed allocation and blinded assessment of some outcomes. Setting: Two tertiary medical centres in the USA. Participants: Adults in a medical intensive care unit (ICU) who had been on mechanical vent...

background : children suffering from cancer always require pain relief and reduce anxiety when undergoing painful procedures. the aim of this study is to compare the effect of pethedine and ketamine administration in cancer-diagnosed children undergoing bone marrow aspiration and biopsy procedures. subjects and methods : a randomized, double-blinded, crossover trial was carried out on 57 childr...

BACKGROUND State of the art sedation concepts on intensive care units (ICU) favor propofol for a time period of up to 72 h and midazolam for long-term sedation. However, intravenous sedation is associated with complications such as development of tolerance, insufficient sedation quality, gastrointestinal paralysis, and withdrawal symptoms including cognitive deficits. Therefore, we aimed to inv...

Management of analgesia and sedation in the intensive care unit requires evaluation and monitoring of key parameters in order to detect and quantify pain and agitation, and to quantify sedation. The routine use of subjective scales for pain, agitation, and sedation promotes more effective management, including patient-focused titration of medications to specific end-points. The need for frequen...

Abstract Objective To compare the effects of a pain management program and routine suctioning methods on level presence agitation in Chinese adults admitted to intensive care unit. disseminate results from implementation evidence-informed interventions for reducing during endotracheal tube (ETS) translate key finding clinical nursing practice. Methods A quasi-experimental study two-group post-t...

INTRODUCTION There is increasing evidence that deep sedation is detrimental to critically ill patients. The aim of this study was to examine effects of deep sedation during the early period after ICU admission on short- and long-term survival. METHODS In this observational, matched-pair analysis, patients receiving mechanical ventilation that were admitted to ICUs of a tertiary university hos...

OBJECTIVES To evaluate the clinical effectiveness, safety, and cost of dexmedetomidine for the treatment of agitated delirium refractory to haloperidol in nonintubated critically ill patients. DESIGN Nonrandomized, controlled trial. SETTING Intensive care department of a tertiary care nonprofit hospital. PATIENTS All consecutive admissions to a medical-surgical ICU with a diagnosis of agi...