A process of producing a receptor in HEK-293 cells used for the drug discovery program at Pfizer Inc. has been successfully developed with a novel BelloCell bioreactor to replace the conventional 2-D cell culturing devices including Cell Factories and roller bottles. A single BelloCell-500 has produced >1.4 x 10(9) HEK-293 cells, which are equivalent to those produced by 12 roller bottles, with...

The first roller pump was patented in 1855 by Porter and Bradley and was hand operated. A modification first named "surgical pump", designed and manufactured by E. E. Allen in 1887, was intended for direct blood transfusion. Truax, who also distributed and promoted the Allen pump with one roller, developed the first double roller pump in 1899. In the following decades, several researchers, incl...

to reduce the storing space and handling costs for hay/straw bales, recompressing the original bales after adequate hay drying is recommended. in this project, a recompression machine was designed, constructed and evaluated. solidwork and nastran software were employed to model, and to analyze the stresses in the components of the machine, respectively. the components of the machine consisted o...

In the process of steel bar straightening processing, rollers are often damaged by fatigue due to uneven force, which causes frequent replacement rollers. Therefore, structural parameters optimization machine is very important improve machining accuracy and prolong service life roller. this paper, an method based on particle swarm (PSO) algorithm was proposed used optimize machine. First, main ...

The article presents an effective new constructive scheme and the principle of operation exhaust device ring spinning machine. mathematical model results solving problem oscillations axis composite squeezing roller drawing apparatus machine have been determined. recommended values parameters are given. Based on analysis research conditions for obtaining high-quality yarn, parameter each rollers...

In an estuary, a tidal bore may be generated at the leading edge of the flood tidal wave during the early flood tide under spring tide conditions into a narrow funnelled channel. For Froude numbers greater than 1.4–1.6, the leading edge of the bore is characterised by a breaking roller. The roller is characterised by a sudden increase in water depth, a highly turbulent flow with large-scale vor...

The binary ink developer in the HP-Indigo press selectively applies condensed ElectroInk® onto the photoreceptor to form the image. The ink is transported by the elastomeric developer roller, which needs to be sufficiently conductive to allow its surface voltage remains constant as it moves through the various interfaces encountered along its periphery. But it cannot be so conductive as to disc...

One of the biggest problems of artisans , is notching the high speed steel roller is due to the inability to do this work, become high speed steel roller bearings are disposable. One of the biggest problems of artisans , is notching the high speed steel roller is due to the inability to do this work, become high speed steel roller bearings are disposable.When the roller is placed on the product...

Mechanical properties of copper (Cu) film under grinding process were accomplished by molecular dynamics simulation. A numerical calculation was carried out to understand the distributions of atomic and slip vector inside the Cu films. In this study, the roller rotation velocity, temperature, and roller rotation direction change are investigated to clarify their effect on the deformation mechan...