Obesity increases the risk for a number of diseases including cardiovascular diseases and type 2 diabetes. Excess saturated fatty acids (SFAs) in obesity play a significant role in cardiovascular diseases by activating innate immunity responses. However, the mechanisms by which SFAs activate the innate immune system are not fully known. Here we report that palmitic acid (PA), the most abundant ...

Diets high in saturated fatty acids (SFAs) are associated with the development of circadian dysregulation, obesity, and Type 2 diabetes mellitus. Conversely, polyunsaturated fatty acids (PUFAs) have recently been identified to improve insulin sensitivity, reduce weight gain, and relieve obesity-induced inflammation. While saturated fatty acids, such as the prevalent dietary fatty acid palmitate...

Within the context of reduced-fat diets, the effects of incorporating a fat high in stearic acid and adding moderate amounts of dietary cholesterol were examined in 14 middle-aged and elderly women and men (range, 46 to 78 years) with low-density lipoprotein cholesterol (LDL-C) concentrations > 130 mg/dL (range, 133 to 219 mg/dL) at screening. The subjects consumed each of the five diets, which...

In this study fatty acid contents, because of the importance in human’s life, and their seasonal variations of a dominant bivalve of Haleh Creek were determined for the first time. Fatty acid identification was done by GC-MS (Gas Chromatography–Mass Spectrometry) method. After collecting and dissecting the species from the shells, samples weighed and frozen for further experiments. All the samp...

Background Background: The fatty acid composition of the sperm membrane changes drastically during spermatogenesis and may be key to its function. Previous data has shown that intake of long chain poly-unsaturated fatty acids can change the fatty acid composition of tissues, including testes and sperm. However, whether these changes in composition translate into changes in semen quality or male...

the aim of this study was to determine the fatty acid and mineral composition in bone of 3 pelagic fish: gold stripe sardine (sardinella gibbosa), anchovy kilka (clupeonella engrauliformis) and indian anchovy (stolephorus indicus). fatty acid profiles showed that total saturated fatty acid have no significant differences in 3 species. the content of total mono saturated fatty acids in anchovy k...

From the Magle Stora Kyrkogata 9, Lund, Sweden (U.R.); Saint Luke’s Mid America Heart Institute, Kansas City, MO (J.J.D.); Faculty of Science and Technology, Institute of Clinical Exercise and Health Science, University of the West of Scotland, Hamilton, Lanarkshire, United Kingdom (Z.H.); Department of Comparative Biosciences, University of Illinois at Urbana-Champaign, Urbana (F.A.K.); Instit...

BACKGROUND Stearoyl-CoA desaturase (SCD) is a key enzyme that converts saturated fatty acids (SFAs) to monounsaturated fatty acids (MUFAs) in fat biosynthesis. Despite being crucial for interpreting SCDs' roles across species, the evolutionary relationship of SCD proteins across species has yet to be elucidated. This study aims to present this evolutionary relationship based on amino acid seque...

BACKGROUND It is uncertain whether saturated fatty acids (SFAs) impair endothelial function and contribute to arterial stiffening. OBJECTIVE We tested the effects of replacing SFAs with monounsaturated fatty acids (MUFAs) or carbohydrates on endothelial function and arterial stiffness. DESIGN With the use of a parallel-designed randomized controlled trial in 121 insulin-resistant men and wo...