The aptamer-functionalized hydrogel diffraction gratings were successfully fabricated by incorporating an aptamer and its complementary sequence as crosslinking junctions in the network structure. The gratings showed a sensitive response to human thrombin as read out from the diffracted light.

Environmentally sensitive hydrogels have enormous potential in various applications. Some environmental variables, such as low pH and elevated temperatures, are found in the body. For this reason, either pH-sensitive and/or temperature-sensitive hydrogels can be used for site-specific controlled drug delivery. Hydrogels that are responsive to specific molecules, such as glucose or antigens, can...

Integration of photo-sensitive spiropyran with dipeptide d-Ala-d-Ala in one small molecule resulted in a hydrogelator which can form supramolecular hydrogel with responses not only to light but to ligand-receptor interaction.

In this study, a biodegradable thermo-sensitive hydrogel from poly(trimethylene carbonate)15-F127-poly(trimethylene carbonate)15 (PTMC15-F127-PTMC15) was designed and evaluated as an injectable implant during ocular glaucoma filtration surgery in vivo and in vitro. Mitomycin C (MMC) was loaded into this hydrogel for controlled released to prolong the efficacy and to reduce the long-term toxicit...

to reduce peat while increasing the water holding capacity (whc) of casing soil in button mushroom production an experiment was conducted in 2006 with three hydrogel treatments of: t0= casing soil with no hydrogel, as control, t1= casing soil + 10% hydrogel (v/v), and t2= casing soil + 20% hydrogel (v/v) with three replicates in a completely randomized design. results indicated that treatment 1...

Adsorption and controlled release of terbinafine hydrochloride (TER-HCl) to and from pH sensitive poly(acrylamide/maleic acid) (P(AAm/MA)) hydrogels were investigated. P(AAm/MA) hydrogels were prepared by irradiating the ternary mixtures of AAm/MA/and water by gamma-rays at ambient temperature. Antifungal drug, TER-HCl containing hydrogels, at different drug to polymer ratios, was prepared by d...

Thermo-sensitive hydrogels were prepared by graft copolymerization of Polyvenylalcohol and chitosan with N-Isopropylacrylamide via gamma radiation. Characterization of hydrogels such as DSC analysis and swelling and solubility tests in different ratios were investigated. DSC and solubility analysis showed chitosan and PVA and NIPAAm monomer were grafted via gamma radiation successfully. Results...

Although microRNAs (miRNAs) have been shown to be excellent indicators of disease state, current profiling platforms are insufficient for clinical translation. Here, we demonstrate a versatile hydrogel-based microfluidic approach and novel amplification scheme for entirely on-chip, sensitive, and highly specific miRNA detection without the risk of sequence bias. A simulation-driven approach is ...

In this work a pH-sensitive poly(acrylamide-co-itaconic acid)/ graphite composite hydrogel is prepared by free radical initiated polymerization of monomers acrylamide(Am) and itaconic acid(IA) in the presence of settled graphite(Gt) particles using N,N’-methylene bisacrylamide(MB) as cross linker in aqueous medium. The SEM analysis revealed almost uniform distribution of grafite particles withi...

A new type of biosensor is proposed that combines the recognition properties of "intelligent" hydrogels with the sensitivity and reliability of microfabricated pressure transducers. In the proposed device, analyte-induced changes in the osmotic swelling pressure of an environmentally responsive hydrogel are measured by confining it within a small implantable enclosure between a rigid semipermea...