Background and Aims: Neonatal sepsis is considered a clinical syndrome characterized by signs and symptoms of infection associated with positive blood culture. The present study investigates the rate of sensitivity and resistance to antibiotics in neonates with definite sepsis. Materials and Methods: This cross-sectional study was conducted on 268 neonates with definitive sepsis (positive bloo...

UNLABELLED In sepsis, the systemic inflammatory response is adapted to the etiologic agent and the increase in the level of mediators is associated with organ dysfunction. Currently, a rapid assessment of patient ability to develop an adequate immune response is not possible, the response mechanisms being similar in the context of different etiological agents. AIM To find statistical argument...

Lemierre syndrome is caused by an infection in the oropharyngeal region with subsequent thrombophlebitis in the internal jugular vein. The thrombus from the thrombophlebitis can invade other vital organs, such as liver, lungs, or joints, resulting in secondary infection, which further exacerbates the fatal prognosis of this syndrome. Lemierre syndrome, also called postanginal sepsis or necrobac...

N Engl J Med 2004;351:159-69. Copyright © 2004 Massachusetts Medical Society. cute renal failure occurs in approximately 19 percent of patients with moderate sepsis, 23 percent with severe sepsis, and 51 percent with septic shock when blood cultures are positive (Tables 1 and 2). 1,2 A progressive increase in the acute respiratory distress syndrome also occurs with moderate and severe sepsis an...

Acquired abnormalities in platelets, endothelium, and their interaction occur in sepsis, immune heparin-induced thrombocytopenia (HIT), and the antiphospholipid syndrome. Although of distinct pathogeneses, these three disorders have several clinical features in common, including thrombocytopenia and the potential for life- and limb-threatening thrombotic events, ranging from microvascular (seps...

OBJECTIVE To measure serum nitrite and nitrate levels in critically ill children as indicators of endogenous nitric oxide (NO) production. HYPOTHESIS Endogenous NO production is increased in children with conditions characterised by immune stimulation. DESIGN Prospective descriptive study in a multidisciplinary paediatric intensive care unit. PATIENTS 137 consecutive critically ill childr...

Iultiple organ failure (MOF) denotes a clinical syndrome that is characterized by a process of dysfunction and ultimately failure of vital organs. Commonly found in association with infection in critically ill patients,’ it has supplanted refractory hypoxemia as the major cause of late mortality in patients with the adult respiratory distress syndrome (ARDS).2 Although ARDS is often an initial ...