The serotonin 2A receptor is one of the most abundant serotonin receptors in the human CNS and is a target for drugs designed to treat psychiatric disorders (McCorvy and Roth, 2015). Significantly, levels of serotonin 2A receptors have been shown to be altered in the CNS of subjects with schizophrenia (Dean, 2003), major depressive disorders (Arora and Meltzer, 1989; Dean et al., 2014) and suic...

Neuronal nicotinic alpha7 subunits assemble into cell-surface complexes that neither function nor bind alpha-bungarotoxin when expressed in tsA201 cells. Functional alpha-bungarotoxin receptors are expressed if the membrane-spanning and cytoplasmic domains of the alpha7 subunit are replaced by the homologous regions of the serotonin-3 receptor subunit. Bgt-binding surface receptors assembled fr...

Serotonergic signaling appears to play a key role in the generation and modulation of various cognitive, behavioral, and developmental processes. The serotonin(1A) receptor is an important member of the superfamily of seven transmembrane domain G-protein-coupled receptors and is the most extensively studied among the serotonin receptors. Several aspects of serotonin(1A) receptor biology such as...

curcumin exhibits both cancer- preventive activity and growth inhibitory effects on several neoplastic cells including human colon cancer. serotonin and its receptors have also been implicated in tumor development. this study investigated the effect of ritanserin, a selective serotonin 5ht2a receptor antagonist, alone and in combination with curcumin on colorectal cancer cell lines. results sho...

This short review addresses immune functions of platelet serotonin. Platelets transport serotonin at a high concentration in dense granules and release it upon activation. Besides haemostatic, vasotonic and developmental modulation, serotonin also influences a variety of immune functions (mediated by different serotonin receptors). First, platelet serotonergic effects are directed against invad...

A correlation between high plasma serotonin levels and total pulmonary resistance was reported in more than 80% of pulmonary hypertensive patients. When submitted to chronic hypoxia (10% O2 for more than 3 weeks), wildtype mice develop lung vascular remodeling and pulmonary hypertension. We previously reported that, by contrast, the development of these hypoxiadependent alterations is totally a...

Decreased serotonergic activity has been implicated in anxiety and major depression, and antidepressants directly or indirectly increase the long-term activity of the serotonin system. A key component of serotonin circuitry is the 5-HT1A autoreceptor, which functions as the major somatodendritic autoreceptor to negatively regulate the "gain" of the serotonin system. In addition, 5-HT1A heterore...

The 5-HT 1A receptor is a subtype of serotonin receptor located in presynaptic and postsynaptic regions. Activation of this receptor has been involved in the mechanism of action of anxiolytic, antidepressant and antipsychotic medications. Serotonin is a monoamine neurotransmitter that interacts with 14 serotonin (5-HT) receptors that can be subdivided into 7 classes [1]. Specifically, the 5-HT ...

Latent inhibition (LI) is a decrement in learning performance that results from the nonreinforced pre-exposure of the to-be-conditioned stimulus, in both vertebrates and invertebrates. In vertebrates, LI development involves dopamine and serotonin; in invertebrates there is yet no information. We studied differential olfactory conditioning of the proboscis extension response in the honeybee Api...

For decades, it has been widely believed that serotonin has a major role in regulating gastrointestinal (GI) function for review see Gershon and Tack (2007). This belief is based on a huge number of different findings. These include the well known observation that most of the body’s serotonin is synthesized and stored in the intestine, the presence of many different serotonin receptors within t...