background and aims. oral lichen planus is a relatively common chronic oral mucosal disease of unknown etiology. regarding numerous studies on the immunologic factors involved in the etiology of lichen planus, the present study evaluated the serum interleukin-17 (il-17) level in patients with erosive and non-erosive oral lichen planus. materials and methods. this descriptive analytical study in...

BACKGROUND The current study aimed at testing the effect of corticosteroid therapy on serum levels of interleukin-10 (IL-10) and IL-17 as well as lncRNA-AF085935 in patients of rheumatoid arthritis (RA) associated with hepatitis C virus (HCV) and evaluating the usefulness of using these parameters to predict the therapeutic efficacy of steroids in these patients. METHODS Thirty healthy contro...

BACKGROUND Interleukin-37 (IL-37), a member of IL-1 family, is primarily an anti-inflammatory cytokine, which reduces systemic and local inflammation. However, the expression and role of IL-37 in Graves' disease (GD) remains unknown. This study aims to measure the levels of serum and peripheral blood mononuclear cells (PBMCs) IL-37 in patients with Graves' disease and to examine its association...

Introduction Alzheimer’s disease (AD) is a degenerative brain and the most common cause of dementia. Evidence suggests that various cytokines, including interleukins (IL) IL-6, IL-10, IL-12 are actively involved in pathogenesis AD. The role IL-17 IL-23 less clear. Objectives To investigate correlations between IL-17, IL-23, neurocognitive scales patients with disease. Methods study included 45 ...

Recent studies have demonstrated that T-helper 17 lymphocytes (Th17), which produce mostly IL-17, play a major role in several autoimmune diseases commonly thought to be Th1-related, including Hashimoto's thyroiditis (HT). IL-23, a member of the IL-12 cytokine family, is known to guide T cells toward the Th17 phenotype and its serum levels are increased in several autoimmune disease. Few data a...

primary sjögren's syndrome (pss) is a common autoimmune disease involving abnormal th17 activation. the aim of the current study was to investigate the immunosuppression effect of cyclosporine a (cys a), a potent immunosuppressor on the proliferation and activation of t cells, on the activation of th17 cells. blood samples from both inactive and active pss patients as well as healthy controls w...

introduction: depression is a mental disorder that highly associated with immune system. therefore, this study compares the serum concentrations of il-21, il-17, and transforming growth factor β (tgf-β) between patients with major depressive disorder and healthy controls. methods: blood samples were collected from 41 patients with major depressive disorder and 40 healthy age-matched controls wi...

PURPOSE To investigate the profile of T-helper type 17 (Th17) cell-related cytokines (interleukin-23 [IL-23], IL-27, IL-17 and interferon-γ [IFN-γ]) in postoperative inflammation in patients with Behcet disease (BD) after cataract surgery. METHODS Serum was collected from seven BD patients with complicated cataract, and from nine controls with uncomplicated cataract, before cataract surgery, ...