Introduction: Sleep disorders are common problems in modern societies affecting different aspects of individuals' lives. Many studies have reported that sleep deprivation (SD) leads to impairments in hippocampus-dependent learning and memory formations. Physical exercise has been shown to improve learning and memory. The objective of the current study was to investigate the effects of Voluntary...

We estimate prevalence, incidence and persistence of short sleep or sleep deprivation in a two wave cohort study of 4175 youths 11-17 years old at baseline and 3134 of these a year later. Data were collected using computer interviews and questionnaires. Sleep deprivation was defined as 6h or less per night during the past 4 weeks. Weighted logistic regression procedures were employed to calcula...

STUDY OBJECTIVES To examine the prospective, reciprocal association between sleep deprivation and depression among adolescents. DESIGN A community-based two-wave cohort study. SETTING A metropolitan area with a population of over 4 million. PARTICIPANTS 4,175 youths 11-17 at baseline, and 3,134 of these followed up a year later. MEASUREMENTS Depression is measured using both symptoms of...

Sleep is critical for repair as well as the rejuvenation processes in the body and many of these functions are regulated via underlying cellular metabolic homeostasis. Changes in sleep pattern are reported to alter such metabolic function resulting in altered disease susceptibility or behavior. Here, we measured the extent to which overnight total sleep deprivation (SD) in young adult humans ca...

OBJECTIVE One night of sleep deprivation induces a transient improvement in about 60% of depressed patients. Since depression is associated with abnormalities of the hypothalamic-pituitary-adrenal (HPA) axis, the authors measured cortisol secretion before, during, and after therapeutic sleep deprivation for 1 night. METHOD Fifteen unmedicated depressed inpatients participated in a combined po...

background and objective : sleep deprivation (sd) is caused by a host of reasons and has numerous consequences on cardiac system. in this study, we aimed to assess the preconditioning effects of acute sd on ischemia (is)-induced ventricular arrhythmias in isolated rat hearts. materials and methods : male wistar rats randomly were placed into the four groups: is-group, acute sd group, control gr...

Current antipsychotic medications fail to satisfactorily reduce negative and cognitive symptoms and produce many unwanted side effects, necessitating the development of new compounds. Cross-species, experimental behavioural model systems can be valuable to inform the development of such drugs. The aim of the current study was to further test the hypothesis that controlled sleep deprivation is a...

BACKGROUND Clinical depression is associated with abnormalities of the hypothalamic-pituitary-thyroid axis. Changes in thyroid function during sleep deprivation may be related to its antidepressant effects. METHODS Levels of thyroid-stimulating hormone, tri-iodothyronine, tri-iodothyronine uptake, thyroxine, and free thyroxine were measured before, during, and after a 48-hour sleep deprivatio...

OBJECTIVE Arousal (AR) from sleep is associated with an autonomic reflex activation raising blood pressure and heart rate (HR). Recent studies indicate that sleep deprivation may affect the autonomic system, contributing to high vascular risk. Since in sleep disorders a sleep fragmentation and a partial sleep deprivation occurs, it could be suggested that the cardiovascular effects observed at ...