The effects of two chemical agents − sodium nitrite and phenobarbital (PB) applied separately or in combination, on the activity of enzymatic components of monooxigenase system of hepatocytes, the stability of liver lysosomes and peroxisomes as well as on the total activity of marker enzymes for these structures were investigated in male rats. Following the combined administration of both agent...

Hypertension is a common disease that includes oxidative stress as a major feature, and oxidative stress impairs physiological nitric oxide (NO) activity promoting cardiovascular pathophysiological mechanisms. While inorganic nitrite and nitrate are now recognized as relevant sources of NO after their bioactivation by enzymatic and non-enzymatic pathways, thus lowering blood pressure, mounting ...

McQuiston T. A. C. (1936) Poisoning with sodium nitrite. Lancet 2, 1153-1154. Polson C. J. & Tattersall R. N. (1969) Clinical Toxicology 2nd Ed, pp. 109-116. Pitman Medical, London. Shesser R., Mitchell J. & Edelstein S. (1981) Methaemoglobinaemia from isobutyl nitrite preparations. Annals of Emergency Medicine 10, 262-264. Walley T. & Flanagan M. (1987) Nitrite induced methaemoglobinaemia. Pos...

INTRODUCTION Acute myocardial infarction (AMI) is a major cause of death and disability in the UK and worldwide. Presently, timely and effective reperfusion with primary percutaneous coronary intervention (PPCI) remains the most effective treatment strategy for limiting infarct size, preserving left ventricular ejection fraction (LVEF) and improving clinical outcomes. However, the process of re...

RATIONALE Abnormalities in nitric oxide signaling play a pivotal role in heart failure with preserved ejection fraction (HFpEF). Intravenous sodium nitrite, which is converted to nitric oxide in vivo, improves hemodynamics in HFpEF, but its use is limited by the need for parenteral administration. Nitrite can also be administered using a novel, portable micronebulizer system suitable for chroni...

The intake of nitrite in sausages is a concern for health-conscious consumers. This study investigated the effects heating method (smokehouse, water bath, or ohmic heating), temperature (40, 60, 75°C), sodium level (80 250 ppm), and frozen storage period (≤3 days 4 weeks) on residual nitrite, pigments, curing efficiency chicken sausages. results indicated that electrical conductivities samples ...

Taurine was extracted from Pegasus laternarius Cuvier to study its effects on learning and memory in mice. Mice were treated with different doses of taurine (10 mg/kg, 20 mg/kg, 40 mg/kg). The mice were treated with various chemical agents (pentobarbital, cycloheximide, sodium nitrite, alcohol) to disrupt the normal memory process. We measured the effect of taurine on step-down latency (SDL) an...

The effects of meat-curing agents on germination and outgrowth of putrefactive anaerobe 3679h (PA 3679h) spores were studied in microcultures. Nitrite concentrations up to 0.06% at pH 6.0 or between 0.8 and 1% at pH 7.0 allowed emergence and elongation of vegetative cells but blocked cell division. The newly emerged cells then lysed. With more than 0.06% nitrite at pH 6.0 or more than 0.8 to 1%...