نتایج جستجو برای: spontaneous alternation behaviour

تعداد نتایج: 296851  

Journal: :Osong public health and research perspectives 2016
Yu-Jin Choi Yun-Sik Choi

OBJECTIVES Nonionizing radiation is emitted from electronic devices, such as smartphones. In this study, we intended to elucidate the effect of electromagnetic radiation from smartphones on spatial working memory and progenitor cell proliferation in the hippocampus. METHODS Both male and female mice were randomly separated into two groups (radiated and control) and the radiated group was expo...

Journal: :The international journal of neuropsychopharmacology 2013
Jordan W Brown Caroline A Whitehead Ana M Basso Lynne E Rueter Min Zhang

Cognitive deficits associated with schizophrenia (CDS) are implicated as a core symptom cluster of the disease and are associated with poor daily life functioning. Unfortunately, current antipsychotic agents provide little alleviation of CDS, representing a critical unmet therapeutic need. Here we investigated the effects of ABT-239 and A-431404, non-imidazole histamine H(3) receptor (H(3)R) an...

Background and Objective: Epilepsy is a long-lasting central nervous system disorder that is accompany with spontaneous seizures and insufficiency in learning and memory. Now drug treatment is the most common therapy but some patients do not research to suitable control of their seizures with current drugs. Hence, new treatment is needed to help those patients that are unaffected to existing dr...

2015
Ying Zhou Kimie Niimi Weidong Li Eiki Takahashi

Neuronal voltage gated calcium channels (VGCCs) including Cav2.1 and Cav2.2 channels mediate the presynaptic machinery for vesicular release of neurotransmitters. However, the role of different VGCCs in the neural circuits underlying spatial short-term memory has not been studied. Although it has been reported that spatial cognition requires Cav2.1-regulated signaling in the hippocampus, Cav2.2...

Introduction: Methadone has been used as a drug to detoxify opioid tolerance. Naloxane precipitated morphine withdrawal behaviours were attenuated by venlafaxine as an antidepressant. On the contrary, after detoxifying the opioids, spontaneous withdrawal syndrome may occur with pain sensitivity. Therefore the present study aimed to examine the effects of chronic methadone (70 mg/kg, in dr...

Journal: :journal of basic and clinical pathophysiology 2015
tourandokht baluchnejadmojarad nida jamali-raeufy mehrdad roghani farnaz nikbakht samira ramazi

background and objective: epilepsy is a long-lasting central nervous system disorder that is accompany with spontaneous seizures and insufficiency in learning and memory. now drug treatment is the most common therapy but some patients do not research to suitable control of their seizures with current drugs. hence, new treatment is needed to help those patients that are unaffected to existing dr...

Journal: :Behavioural brain research 2013
Dana L M Campbell Jamie A Dallaire Georgia J Mason

Studies spanning 15 species (including American mink, Neovison vison) demonstrate that within similarly-housed populations, individuals displaying high levels of stereotypic behaviour (SB) typically show perseverative responding (e.g. during set-shifting, or reversal/extinction learning). Similar correlations in autism and schizophrenia suggest this indicates captivity-induced cortico-striatal ...

2017
Hélène F E Gleitz Claire O'Leary Rebecca J Holley Brian W Bigger

Severe mucopolysaccharidosis type II (MPS II) is a progressive lysosomal storage disease caused by mutations in the IDS gene, leading to a deficiency in the iduronate-2-sulfatase enzyme that is involved in heparan sulphate and dermatan sulphate catabolism. In constitutive form, MPS II is a multi-system disease characterised by progressive neurocognitive decline, severe skeletal abnormalities an...

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