Formation of N-nitroso compounds in gastric juice has been implicated in the pathogenesis of cancer in the stomach after operation. Gastric juice was aspirated from 85 subjects: 23 were controls, 51 had previously undergone vagotomy and gastrojejunostomy, and 11 had previously undergone vagotomy and pyloroplasty. The gastric juice samples were analysed for pH, nitrite, and total N-nitroso compo...

As the result of extended studies on pernicious anemia, Ternberg and Eakin (1) have recently demonstrated the presence in normal gastric juice of a protein fraction, apoerythein, which is absent from the gastric juice of pernicious anemia patients. This substance is capable of combining with vitamin I312 (erythrotin) to form a vitamin-protein complex, erythein, in which the vitamin is resistant...

The presence of ascorbic acid in gastric juice may protect against gastric carcinoma and peptic ulceration. This study examined the effect of Helicobacter pylori (H pylori) on the secretion of ascorbic acid into gastric juice by measuring fasting plasma and gastric juice ascorbic acid concentrations in patients with and without the infection and also before and after its eradication. Gastric ju...

The establishment of normal standards of gastric function is a prerequisite to the recognition of abnormal conditions. Such standards have heretofore been inadequate, with the result that studies of stomach secretion have fallen into disfavor in the clinic. As we pointed out in a previous paper (1), a test of function must be based on certain general criteria: (1) the test must be applied under...

Dietary factors are thought to be closely associated with the development of human cancers and hence numerous studies in this area have already been conducted in the United States and other Western countries. Comparatively few prospective studies have been published in Japan, especially for Hokkaido people. The present investigation was therefore performed to assess links between four leading c...

This study reports the electrophoretic pattern of the proteins in human gastric juice of control patients and patients with gastric ulcer and gastric carcinoma. Autodigestion was prevented by intragastric neutralization. The statistical limits of normal are defined and the changes found in the gastric juice of gastric ulcer and gastric patients with gastric carcinoma described.

A fluorometric method for the determination of N-nitroso-N-methylurea (NMU) has been developed. It is based on the N-methylation reaction of nicotinamide with NMU and a subsequent condensation reaction with acetophenone, followed by an acid treatment to form a fluorescent 2,7-naphthyridine derivative. This method enabled the determination of NMU in the range 0.05 - 2 nmol/200 microl with a rela...

The protective and lubricative r6le of mucus in the gastro-intestinal tract has been reported and studied by many investigators (Claude Bernard (4), Schiff (18), de Klug (12), Whitlow (19), Elliott (7), Pavlov (16), Berg and Jobling (3), Leriche (14), and Bucher (6)). An absolute or relative deficiency of gastric mucus has been frequently suggested as a possible etiologic factor in gastro-duode...

In recent years, remarkable progress has been made in the research of injectable hydrogel for internal tissue healing. However, therapeutic outcome is usually limited when used treatment gastric perforation due to high acidic juice and violent deformation wall. Regarding these challenges, we proposed an ionic nano-reservoir (INR)-based dual-network hydrogel, which excellent adhesion mechanical ...

In studying gastric secretion it has been customary to promote the flow of juice by some sort of artificial stimulus, whether food or drug, and such a procedure is of obvious importance where the digestive capabilities of the stomach are under consideration. There is, however, another aspect of stomach function which is of value in clinical medicine, namely an assay of the secretions under rest...