The alkylating proficiency of sulfur-containing mustards may be increased by using an acridine moiety to guide the sulfur mustard to its cellular target. In this study, the interactions of a new series of sulfur-containing acridine ligands, some that also function as alkylating mustards, with DNA were evaluated by electrospray ionization mass spectrometry (ESI-MS). Relative binding affinities w...

introduction: sulfur mustard (sm), a toxic alkylating gas, can cause serious long-term pulmonary complications such as chronic obstructive pulmonary disease (copd). metabolic syndrome (mets) is one of the important comorbidities of copd. this study was designed to evaluate the frequency of metabolic syndrome in iranian chemical warfare patients (cwps) with copd. materials and methods: thirty cw...

background: sulfur mustard (sm) as a chemical warfare agent, increases permeability of bronchial vessels and damages airway epithelium. sm exposure causes debilitating respiratory complications. this study was designed to evaluate clinical respiratory manifestations, and to compare chest x ray (cxr) and high resolution computed tomography (hrct) scan of chest in sm exposed patients with respira...

sulfur mustard (sm, bis- (2-chloroethyl) sulphide) is a chemical warfare agent that causes dna alkylation, protein modification and membrane damage. sm can trigger several molecular pathways involved in inflammation and oxidative stress, which cause cell necrosis and apoptosis, and loss of cells integrity and function. epigenetic regulation of gene expression is a growing research topic and is ...

In the last few years many chemically injured patients have been visited throughout the country in order to investigate the late respiratory complications of sulfur mustard. 35 patients who were previously admitted for mustard poisoning underwent complete clinical examination as well as spirometry, fiberoptic bronchoscopy (FOB), Bronchoalveolar lavage (BAL), and trans bronchial lung biopsy...

introduction: chronic obstructive pulmonary disease (copd) secondary to sulfur mustard gas poisoning, known as mustard lung, is a major late pulmonary complications in chemical warfare patients. serious comorbidities like dyslipidemia are frequently encountered in copd. the aim of this study was to measure the serum lipid profile and evaluate the relation of lipid parameters with the severity o...

conclusions inhalation of tiotropium bromide in combination with pulmonary rehabilitation could improve some plethysmographic lung volumes and clinical outcomes in patients with chronic pulmonary disease due to sm. short-term prescription of pulmonary rehabilitation has no effect on cpet of patients. patients and methods in a randomized clinical trial, using convenient sampling method, 54 patie...

Background: Sulfur mustard (SM) is a chemical blistering warfare that affects different organs especially hematopoietic system. Prevalence of acute myeloblastic and lymphoblastic leukemia is increased by sulfur mustard exposure. FLT3-ITD mutation can be effective on leukemogenesis. Therefore, the aim of this study was to verify the frequency of FLT3-ITD mutation in the patients who exposed to S...

Sulfur mustard (SM) or mustard gas is a chemical alkylating agent that causes blisters in the skin (blister gas), burns the eyes and causes lung injury. Some major cellular pathways are involved in the damage caused by mustard gas such as NF-κb signaling, TGF-β signaling, WNT pathway, inflammation, DNA repair and apoptosis. MicroRNAs are non-coding small RNAs (19-25 nucleotides) that are involv...