نتایج جستجو برای: sustained virological response
تعداد نتایج: 1045619 فیلتر نتایج به سال:
BACKGROUND The optimal treatment for hepatitis C patients unresponsive to interferon is unclear. High-dose induction interferon may enhance early viral clearance, whilst ribavirin reduces relapse; in combination, they may improve sustained virological response rates. AIM To compare the efficacy and safety of re-treatment with interferon induction, with or without ribavirin, in interferon non-...
BACKGROUND Direct acting antivirals for hepatitis C virus have shown dramatic results in clinical trials. However, their effectiveness has yet to be demonstrated within observational cohorts which lack exclusion criteria found in randomized control trials. AIM To determine the effectiveness of dasabuvir/ombitasvir/paritaprevir/ritonavir in achieving sustained virological response. METHODS R...
Marijuana use in hepatitis C infection does not affect liver biopsy histology or treatment outcomes.
BACKGROUND Marijuana smoking is prevalent among hepatitis C virus-infected patients. The literature assessing the influence of marijuana on liver disease progression and hepatitis C virus antiviral treatment outcomes is conflicting. METHODS The authors evaluated hepatitis C virus RNA-positive patients followed at The Ottawa Hospital Viral Hepatitis Clinic (Ottawa, Ontario) from 2000 to 2009. ...
Liver biopsy is historically the gold standard for liver fibrosis assessment of chronic hepatitis C patients. However, with introduction and validation noninvasive tests (NITs) to evaluate advanced fibrosis, direct-acting antiviral agents treatment virus (HCV), role NITs have become even more complex. There now need longitudinal monitoring elucidation cutoff values prediction liver-related comp...
conclusions our study comprehensively explored the predictive factors of therapeutic effect of administered drugs and analyzed viral relapse during a six-months to six-year follow-up period from china. the svr may not be the perfect endpoint of hcv therapy in chinese people; we recommend 48 weeks after treatment withdrawal as the suitable time point. patients and methods we retrospectively anal...
BACKGROUND The impact of viral subtype on the rate of sustained virological response (SVR) to antiviral therapy in patients chronically infected with hepatitis C genotype 1 subtype 1a and 1b has not been extensively investigated. The aim of this study is to determine whether the HCV genotype 1 subtypes 1a and 1b respond differently to treatment with PEGylated interferon (PEG-IFN) plus ribavirin...
Hepatitis C therapy in the era of the newer direct-acting antiviral agents has radically changed our treatment schemes by achieving very high rates of sustained virological response. However, treatment with direct antiviral agents fails in a subgroup of patients. This group of so-called difficult-to-treat individuals is the subject of this paper, which reviews the causes of virological failure,...
background previous studies using pegylated interferon (peg-ifn) and ribavirin (rbv) combination therapy suggested that patients with hepatitis c virus (hcv) genotype 1 and low pretreatment hcv rna level who achieved rapid virological response (rvr) can be treated for 24 weeks without compromising sustained virological response (svr) rate. objectives the current study aimed to investigate the e...
background various aspects of adherence to hcv treatment such as frequency, risk factors as well as causes of non-adherence, and its real role in clinical and virological outcome of the infected patients have remained largely unknown. objectives the current study aimed to evaluate patients’ adherence to anti-hcv medications in iran. materials and methods from october 2010 to march 2011, socio-d...
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