objective(s) pde3 has a functional role in insulin secretion and action. we investigated the metabolic effects of new synthetic pde3 inhibitors (mc1, mc2, mc5 and mc6), on mice and hyperglycemic rat. materials and methods the test compound or solvent was injected subcutaneously to mice, for 7 days. on day 8, blood and liver samples were obtained. in hyperglycemic rat, 0.5 g/kg glucose with or w...

Introduction: It was shown in a previous study, that MCPIP, a cilostamide derivative, increased atrial contraction force without changing contraction rate. To improve this property, two new derivatives of cilostamide were synthesized and their effects on PDE3 activity and isolated rat atria contraction were investigated. Methods: The inhibitory effect of each compound on PDE3 enzyme was dete...

the present study was carried out to examine the effect of supplemental dietary valine in the starter diet of broilers (0-15 d of age) on performance, antibodyresponse to newcastle disease virus vaccination and bone mineralization. the experiment was conducted using 300 ross 308 male broilers. one-day-old chicks were randomly allotted to 3 groups; each group consisted of 5 replicate pens with 2...

background: the ketogenic diet (kd), high in fat and low in carbohydrate and protein, provides sufficient protein but insufficient carbohydrates for all the metabolic needs of the body. kd has been known as a therapeutic manner intractable epilepsy. in recent years, the effectiveness of kd drew attention to the treatment of some other disorders such as parkinson’s disease (pd). this study has e...

The effects of food ingredients on iron absorption were investigated by means of long and short term experiments after 59Fe material administration through stomach tubes to male Wistar rats of 200 to 300 grams body weight. The ingredients tested were casein, poultry meat, fish meat and soy protein isolate (SPI) which were contained by 24% in the synthetic food as the protein source. In the form...

we have employed a peptide-based antibody generation protocol for producing antibody against human nestin. using a 12-mer synthetic peptide from repetitive region of human nestin protein devoid of any n- or o-glyco-sylation sequences, we generated a mouse monoclonal antibody capable of recognizing human, mouse, bovine, and rat nestin. a wide variety of nestin proteins ranging from 140-250 kda w...

Antioxidant effect of Herbal product and Synthetic Methionine was evaluated in broilers. Six groups containing 12 birds in each group. Group I served as control fed with basal diet deficient with methionine. Group II served as toxic control fed with cadmium chloride at 100 ppm. Group III and IV served as positive control fed with Methiorep® at 1.4 g/kg diet and synthetic methionine at 1.2 g/kg ...