Context: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), as a novel virus infection, was first detected in China 2019 and has quickly spread pandemic leading to high mortality rate unprecedented challenges for healthcare systems. Although the SARS-CoV-2 clinical spectrum is different, failure of function coagulopathy common manifestation can be observed cases with severe disease (...

Although acclimatization to intermittent hypoxia (IH) improves exercise performance by increasing oxygen delivery and utilization, the effects of chronic IH on platelet-leukocyte interaction and inflammation-related cytokine secretion caused by strenuous exercise remain unclear. This investigation elucidates how two intensities of IH influence eosinophil- and neutrophil-platelet aggregation (EP...

Ischemic stroke accounts for about 87 percent of all cases. It occurs as a result of an obstruction within a vessel of the brain and sudden loss of blood circulation to the corresponding area resulting in the loss of brain function. It is caused by thrombotic or embolic occlusion of an artery and is more common than hemorrhagic stroke. We know that most of the injuries after an acute ischemic s...

This year’s Congress of the International Society Thrombosis and Haemostasis (ISTH) took place in person Montréal, Canada, from June 24-28, 2023. The conference, held annually, highlighted cutting-edge advances basic, translational, population clinical sciences relevant to Society. As for all ISTH congresses, we offered a special, congress-specific scientific theme; this year, special theme was...

Platelet/granulocyte aggregates (PGAs) increase thromboinflammation in the vasculature, and PGA formation is tightly controlled by the complement alternative pathway (AP) negative regulator, Factor H (FH). Mutations in FH are associated with the prothrombotic disease atypical hemolytic uremic syndrome (aHUS), yet it is unknown whether increased PGA formation contributes to the thrombosis seen i...

Background SLE is an inflammatory condition associated with hyperactivation of the immune system, mounting evidence that imbalances in gut microbiota communities are common. These can range from subtle patterns dysbiosis to blooms abundance individual species concordant clinical disease flares. Based on preliminary longitudinal surveys, almost half Lupus nephritis (LN) flares were conc...

Vitamin K dependent protein S (ProS) is a plasma glycoprotein with anticoagulant properties [1]. Its anticoagulant function is well established in the literature based on clinical data, its genetics and on laboratory assays. ProS is able to prolong the clotting time acting as a cofactor for activated protein C. Furthermore, since the 1980’ies it is known that hereditary ProS deficiency (PSD) in...

Background: Currently, the issues of effect anti-B cell therapy on risk severe course COVID-19 in patients (pts) with ANCA-associated vasculitis (AAV) has not been completely studied. Objectives: We present an analysis incidence and outcomes 126 AAV pts treated rituximab (RTX) from one rheumatology center registry. Methods: Data were collected telephone/online surveying between 11-15th November...