OBJECTIVE To identify the diagnostic role of total and free prostate-specific antigen (TPSA and FPSA) in breast cancer in women. METHODS Blood samples of 55 women with breast cancer were prospectively analyzed for PSA before and after breast surgery, with a control group of 82 healthy women. RESULTS Total and free PSA levels were significantly higher in women with breast cancer (preoperativ...

Prostate-specific antigen (PSA) has been widely used as a serum marker for prostate cancer (PCa) screening or progression monitoring, which dramatically increased rate of early detection while significantly reduced PCa-specific mortality. However, a number of limitations of PSA have been noticed. Low specificity of PSA may lead to overtreatment in men who presenting with a total PSA (tPSA) leve...

The decision to take a prostate biopsy is traditionally guided by a digital rectal examination and measurement of serum total prostate-specific antigen (tPSA). However, both techniques are subject to inherent weaknesses. The prostate cancer gene 3 (PCA3), a gene-based marker, specific for prostate cancer, supplements the predictive power of tPSA to improve diagnosis of disease. Including this n...

INTRODUCTION Prostate cancer (CaP) is the most commonly diagnosed cancer among Nigerian men but CaP screening is not a common practice. The true burden of the disease in Nigeria is not known. The study was aimed at studying the community burden of CaP in Lagos. METHODS During a community-based prostate cancer awareness program in 13 local government areas of Lagos, men aged >40 years had seru...

In this study pre-combustion capture of carbon dioxide from hydrogen was performed using a 5A zeolite adsorber. A one column thermal pressure swing adsorption (TPSA) process was studied in the bulk separation of a CO2/H2 mixture (50:50 vol%). The adsorption dynamics of the zeolite bed were investigated by breakthrough experiments to select the suitable range for operational factors in the desig...

BACKGROUND The aim of this study was to develop a method to separate and quantify subforms of free prostate-specific antigen (fPSA) in serum by two-dimensional electrophoresis and to assess the diagnostic accuracy of these subforms for prostate cancer (PCa) diagnosis in comparison with total PSA (tPSA) and the ratio of fPSA to tPSA (%fPSA). METHODS Sera from 50 patients with and without PCa, ...

INTRODUCTION Although prostate cancer (PCa) incidence is lower in HIV+ men than in HIV- men, the usefulness of prostate-specific antigen (PSA) screening in this population is not well defined and may have higher false negative rates than in HIV- men. We aimed to describe the kinetics and predictive value of PSA in HIV+ men. METHODS Men with PCa (n=21) and up to two matched controls (n=40) wit...