During asthma exacerbations, increased airway inflammation may impair the effects of beta(2)-adrenoceptor (beta(2)AR) agonists. It is unclear whether this impairment is prevented by inhaled glucocorticoids (GCs). We have investigated the relaxation of carbachol-contracted mouse tracheal segments to the beta(2)AR agonists formoterol, terbutaline, and salmeterol. The segments were pre-exposed for...

Key points † Optimizing tracheal sealing is of clinical interest: fluid leakage past the tube cuff plays an important role in the pathogenesis of VAP. † Tapered shaped tube cuff offering a sealing zone with reduced folds and channels is a new strategy to minimize fluid leakage past the tracheal tube cuff. † Tracheal tube cuffs made from PVC show much more and faster fluid leakage than cuffs mad...

Tracheal diameter can be assessed from a thoracic radiograph, with assessment of tracheal diameter in dogs based on ratios between tracheal diameter and a skeletal measurement. Reference intervals are not, however, available for the cat. Tracheal narrowing may cause significant clinical problems, although tracheal hypoplasia in dogs may be clinically silent, and is rarely reported in cats (both...

OBJECTIVES COPD has been reported in workers exposed to particulates, and there is increasing evidence that high levels of ambient particulate pollutants may also be associated with COPD. The studies here investigate the hypothesis that particulates, including air pollution particles, can induce airway wall fibrosis, a process that can lead to COPD. DESIGN Rat tracheal explants were exposed t...

Peptides with potent broad-spectrum antibiotic activity have been identified in many animal species. Recent investigations have demonstrated that epithelial cells are a site of antibiotic peptide expression, suggesting that these peptides contribute to host defense at mucosal surfaces. Expression of tracheal antimicrobial peptide (TAP), a member of the beta-defensin family of peptides, is induc...

The tracheoarterial fistula is an unusual but devastating complication of tracheostomy. It occurs with a frequency of approximately 0.7%, and it is uniformly fatal if not recognized and surgically corrected. Mucosal damage from the tracheal cannula, pressure necrosis from high cuff pressure, or mucosal trauma from an improperly positioned cannula tip results in erosion through the tracheal wall...

a twenty-year-old girl was referred with tracheal stenosis (ts) which was a consequence of prolonged intubation after head injury because of previous car accident. the patient was aphasic and had normal respiration. fiberoptic bronchoscopy showed complete tracheal obstruction at second tracheal ring level. distal trachea was normal through tracheostomy tube. removal of the tracheostomy tube and...

mediastinal tracheostomy is a complex surgical procedure for the management of airway reconstruction in patients whose distal trachea is not sufficiently long to be reconstructed as cervical tracheostomy after tracheal resection for malignant diseases. in this article (study), we present our 10 year experience of this uncommon procedure in thoracic surgery ward of imam khomeini's hospital, tehr...

conclusions stents would be regarded as a temporary means of reaching the ideal condition for resection and reconstruction in most patients with tracheal stenoses. although an optimal stent has not been introduced yet, we used polyflex stents in most of our patients with tracheal stenosis due to its availability and ease of use. we suggest that this method is safe and less time consuming than i...