In summary, in order to control tuberculosis, we require a rapid diagnosis of TB patients, who act as the source of disease; and if remain untreated, these patients can spread the disease throughout the population. Therefore, we need to introduce the new approach for quick and accurate identification of Mycobacterium tuberculosis, and CYP141 gene is a new approach for rapid and accura...

Background: Tuberculosis is a major cause of morbidity and mortality in Africa, especially Ghana. Despite the current treatments for tuberculosis, positive treatment outcomes are not attainable due to the differences in the socio-economic and bio-psychological status of the patients. The present study aimed to assess the influential factors in the treatment outcomes of tuberculosis. Methods: T...

background: early pleural tuberculosis (tb) diagnosis is particularly difficult. the aim of this study was to investigate the diagnostic accuracy of the xpert mtb/rif (xpert) (cepheid, sunnyvale, ca) assay using pleural biopsy and pleural fluid specimens in patients with suspected pleural tb but who had a negative sputum acid-fast bacilli (afb) smear. materials and methods: in this study, 134 s...

Tuberculosis remains a major public health problem in both developing and developed countries. Drug-resistant tuberculosis is an increasing health problem and serious challenge to tuberculosis (TB) control programs. Information about the susceptibility pattern of Mycobacterium tuberculosis isolates against anti-tuberculosis drugs is an important aspect to TB control. The objectives of the s...

Drug-resistant tuberculosis is a major public health problem. The aim of this study was to assess the local susceptibility patterns of Mycobacterium tuberculosis and clinical outcomes of drug resistant tuberculosis (DR-TB) at Srinagarind Hospital, a tertiary care center in northeastern Thailand. Between January 2004 and December 2008, 1,052 patients had culture-proven M. tuberculosis infections...

background cigarettes smoking is a risk factor for tuberculosis (tb). associations between smoking and tb disease have been reported, but there are few reports on the influence of smoking on the sputum smear and culture conversion time. this study surveyed the possible association between smoking and sputum smear conversion time among new smear-positive pulmonary tuberculosis patients. patients...

patients and methods in this cross-sectional study, peripheral mononuclear cells (pbmcs) were isolated from peripheral blood of 29 patients with newly diagnosed pulmonary tb and 19 patients with positive tuberculin skin test. the pbmcs were activated with ppd for 72 hours. activated cells were harvested, rna was extracted and cdna was synthesized. a real-time taqman method was designed and opti...

Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis, which usually affects the lungs and can lead to death. Treating infection provides a cure for TB, but involves use of multiple drugs. In this context, pharmacist health professional with skills abilities monitor patients optimize their treatment. Given this, present review aimed gather articles that address pharmac...