PURPOSE To assess the effectiveness of two automated magnetic resonance imaging (MRI) segmentation methods in determining the gross tumor volume (GTV) of brain tumors for use in radiation therapy treatment planning. METHODS AND MATERIALS Two automated MRI tumor segmentation methods (supervised k-nearest neighbors [kNN] and automatic knowledge-guided [KG]) were evaluated for their potential as...

BACKGROUND Numerous oncology combination therapies involving modulators of the cancer immune cycle are being developed, yet quantitative simulation models predictive of outcome are lacking. We here present a model-based analysis of tumor size dynamics and immune markers, which integrates experimental data from multiple studies and provides a validated simulation framework predictive of biomarke...

colorectal cancer (crc) is one of the most common cancers worldwide. understanding of the tumor behavior, in a much closer look, at the molecular level, results in a more effective treatment and accurate prognosis of the disease. from among various genes altered in colorectal cancer k-ras is assumed to be of diagnostic and prognostic significance. k-ras mutations are believed to be a critical e...

estimating the amount of variation due to spatial dependence at different scales provides a basis for designing effective experiments. accurate knowledge of spatial structures is needed to inform silvicultural guidelines and management decisions for long term sustainability of forests. furthermore, geostatistics is a useful tool to describe and draw map the spatial variability and estimation of...

OBJECTIVE To determine the distribution of echogenicity (hypoechoic, isoechoic, or hyperechoic) and predominant intraoperative ultrasonography (IOUS) echogenic appearance of colorectal liver metastasis. The interpatient and intrapatient variability of tumor IOUS echogenicity was assessed. DESIGN Retrospective review of prospectively collected database. SETTING Tertiary cancer center. PATI...

Metachronous (MBC) and synchronous bilateral breast tumors (SBC) are mostly distinct primaries, whereas paired primaries and their local recurrences (LRC) share a common origin. Intra-pair gene expression variability in MBC, SBC, and LRC derives from time/tumor microenvironment-related and tumor genetic background-related factors and pairs represents an ideal model for trying to dissect tumor-r...