نتایج جستجو برای: tumors antibodies
تعداد نتایج: 331953 فیلتر نتایج به سال:
metallothionein (mt) manifests varying expression levels in carcinomas, and they may be considered as valuable cell cancerization biomarkers for diagnosis of patients with cancers. a meta-analysis was conducted to evaluate comprehensively the mt expression difference in various benign tumors and malignant tumors, which compared the high with low mt expression levels in patients of the available...
Survivin is a member of the inhibitor of apoptosis protein (IAP) family and is frequently expressed in cancers, including meningiomas and gliomas. Survivin may be associated with tumor progression and poor prognosis of patients with brain tumors. Using ELISA and immunoblot analysis we asked whether survivin is capable of eliciting a humoral immune response in patients with meningiomas and gliom...
Antibodies and other macromolecular therapeutics can gain access to tumor cells via leaky tumor vessels. Inhibition of vascular endothelial growth factor (VEGF) signaling can reduce the vascularity of tumors and leakiness of surviving vessels, but little is known about how these changes affect the distribution of antibodies within tumors. We addressed this issue by examining the distribution of...
Cutaneous round cell tumors have been classified as mast cell tumor (MCT), histiocytoma (HCT), lymphosarcoma, undif-ferentiated round cell tumors and occasionally rhabdomyosarcoma in veterinary medicine. An adult cock (Gallus domesticus) showing a large solitary integument mass raised on dorso bilateral of cervical part, extending to intercapsular and cranial mid part of the back was referred t...
The use of radioactive tumor-localizing antibodies is developed historically, starting with the demonstration that antibodies can be radioiodinated without destroying antibody activity. Then, antibodies against normal organs were shown to contain antibodies which localize in the normal organ. Subsequently, antibodies capable of localizing in tumors were demonstrated, and these localized well en...
The cytokine TWEAK and its cognate receptor Fn14 are members of the TNF/TNFR superfamily and are upregulated in tumors. We found that Fn14, when expressed in tumors, causes cachexia and that antibodies against Fn14 dramatically extended lifespan by inhibiting tumor-induced weight loss although having only moderate inhibitory effects on tumor growth. Anti-Fn14 antibodies prevented tumor-induced ...
Systemic Delivery of Oncolytic Adenovirus to Tumors Using Tumor-Infiltrating Lymphocytes as Carriers
Immunotherapy with tumor-infiltrating lymphocytes (TIL) or oncolytic adenoviruses, have shown promising results in cancer treatment, when used as separate therapies. When combination, the antitumor effect is synergistically potentiated due adenovirus infection and its immune stimulating effects on T cells. Indeed, studies hamsters a 100% complete response rate animals were treated coding for TN...
conclusions antipospholipid antibodies based on number of abortions and gestational age of abortions were increased. mean antipospholipid and anticardiolipin antibodies in all patients remained in high level just in first 5 years post abortion and then began to fall. results mean age of participants was 24-39 years old. the average rate of antiphospolipid antibodies in patients with normal anti...
PD-1 and its ligands PD-L1 PD-L2 are widely expressed on the surface of a variety cells group costimulatory molecules related to negative immune regulation. The activation PD-1/PD-L1 signaling pathway is beneficial for tumors escape from surveillance, but specific tumor mechanism not yet clear. As far as efficacy anti-PD-1 anti-PD-L1 antibodies concerned, more in-depth research mechanisms still...
Overexpression of the p53 protein, resulting from gene mutations that increase protein stability, has been detected in greater than 25% of primary human breast cancers. In addition, approximately 10% of breast cancer patients have circulating antibodies to the p53 protein. In this study, the anti-p53 humoral response is correlated with the presence and type of mutant p53 protein expressed in th...
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