In this article, optimization-based frameworks are introduced for elucidating the input-output structure of signaling networks and for pinpointing targeted disruptions leading to the silencing of undesirable outputs in therapeutic interventions. The frameworks are demonstrated on a large-scale reconstruction of a signaling network composed of nine signaling pathways implicated in prostate cance...

Introduction Not all of the output from any production process might be desirable. Thus, the inclusion of only desirable output might not provide a true picture of the technical efficiency of a decision making unit. Many production processes have a negative side effect, namely the production of undesirable byproducts. A typical example in health is the death of a patient in the course of admini...

The purpose of this contribution1 is to set up a language to evaluate the results of concerted action among interdependent agents against predetermined properties that we can recognise as desirable from a deontic point of view. Unlike the standard view of logics to reason about coalitionally rational action, the capacity of a set of agents to take a rational decision will be restricted to what ...

The general practice in performance and production efficiency measurement has been to ignore additional products of most transformation processes that can be classified as " undesirable outputs " — which are a subset of the output set. Without the inclusion of these factors, the efficiency evaluation becomes a purely technical measure of the system alone, and does not account for the interactio...

The rapid development of renewable energy enterprises has produced important benefits for contemporary efforts to address serious environmental pollution and depletion fossil resources. However, the that exists in production operation been ignored, so an objective evaluation this issue is becoming urgent. This paper established index system green technology innovation efficiency used dynamic da...

Measuring and improving the efficiency of organizations, as one of the most important parts of the organization's performance evaluation and a tool to control it, is a contemplative issue in order to survive and advance in the area of competition. Transportation is also a key element in the growth and development of countries that creates an unbreakable link among the various sections of the ec...

The improvement of industrial green TFP is crucial for the sustainability economy and environment. And eco-innovation directly improves TFP. However, there are few studies on relation between Based relevant data from 2006-2015 30 provinces in China, using SBM model this study firstly evaluates each province by measuring desirable output undesirable output. Then measured patent application quant...