Previous studies using lipid extracts of heather (Calluna vulgaris) leaves showed the presence of high concentrations of ursolic and oleanolic acid. These two compounds have been reported to present antiviral activity against hepatitis C virus (HCV). In this work, the supercritical fluid extraction of heather was studied with the aim of assessing a potential anti-HCV activity of the extracts ow...

Ursolic acid is a promising candidate for treatment of Chagas disease; however it has low aqueous solubility and intestinal absorption, which are both limiting factors for bioavailability. Among the strategies to enhance the solubility and dissolution of lipophilic drugs, solid dispersions are growing in popularity. In this study, we employed a mixture of the surfactants poloxamer 407 with sodi...

we and other studies have elucidated single molecules that can attenuate aging and extend longevity. indeed, these molecules could prevent age-associated diseases simultaneously and probably extending healthy-life spans. in this review, we discuss recent advances, controversies, opportunities and challenges surrounding ursolic acid (ua) in relationship with aging. in this regard, ua also known ...

Vitex peduncularis, vernacularly known as ‘Charaigorwa’ is a large evergreen tree having numerous ethnopharmacological uses and belongs to the family Lamiaceae. The species globally for its usage cure multifarious human health issues in traditional well contemporary medicines. exerts high bioactivity due presence of several secondary metabolites, including flavonoids, Vitexin, iridoid glycoside...

The leaves of loquat (Eriobotrya japonica) possess high medicinal value and have been used as traditional medicines. However, there are no evidence-based studies on the skin-care effects of E. japonica leaves. To explore new biological activities of E. japonica leaves against skin disorder and to gain a better understanding of the chemical components associated with bioactivities, we evaluated ...

Ursolic acid and related pentacyclic triterpenoids have been isolated and identified as constituents of various berries, particularly cranberries (Vaccinium macrocarpon) and other Vaccinium species. In vitro studies have shown that these compounds possess anti-inflammatory and anti-cancer activities. These compounds reportedly inhibit the growth of numerous tumor cell lines including colon, bre...

Ursolic acid (UA) is a natural terpene compound exhibiting many pharmaceutical properties. In this review the current state of knowledge about the health-promoting properties of this widespread, biologically active compound, as well as information about its occurrence and biosynthesis are presented. Particular attention has been paid to the application of ursolic acid as an anti-cancer agent; i...

Elaeagnus oldhamii Maxim. is a commonly used traditional herbal medicine. In Taiwan the leaves of E. oldhamii Maxim. are mainly used for treating lung disorders. Twenty five compounds were isolated from the leaves of E. oldhamii Maxim. in the present study. These included oleanolic acid (1), 3-O-(Z)-coumaroyl oleanolic acid (2), 3-O-(E)-coumaroyl oleanolic acid (3), 3-O-caffeoyl oleanolic acid ...

BACKGROUND Muscle wasting in chronic kidney disease (CKD) and other catabolic disorders contributes to morbidity and mortality, and there are no therapeutic interventions that regularly and safely block losses of muscle mass. We have obtained evidence that impaired IGF-1/insulin signalling and increases in glucocorticoids, myostatin and/or inflammatory cytokines that contribute to the developme...