نتایج جستجو برای: ursolic acid

تعداد نتایج: 747494  

Journal: :research journal of pharmacognosy 2016
m.h. mirjalili m. ayyari z. bakhtiar m. moridi farimani a. sonboli

background and objectives: betulinic acid (ba), oleanolic acid (oa) and ursolic acid (ua) are well-known pentacyclic triterpenoids (pts), which are produced by plants. they possess a variety of beneficial effects including anti-inflammatory, hepatoprotective, antitumor, anti-hiv, antimicrobial, gastroprotective, and antihyperlipidemic activities. in the present study, quantitative determination...

Journal: :Cancer prevention research 2015
Jiyoon Cho Okkyung Rho Jacob Junco Steve Carbajal Dionicio Siegel Thomas J Slaga John DiGiovanni

In this study, the effects of combining ursolic acid + resveratrol, for possible combined inhibitory effects on skin tumor promotion, were evaluated. Ursolic acid, resveratrol, and the combination of ursolic acid + resveratrol were applied topically prior to 12-O-tetracanoylphorbol-13-acetate (TPA) treatment on mouse skin to examine their effect on TPA-induced signaling pathways, epidermal hype...

2015
EUN-SOOK KIM AREE MOON

Metastasis is a major cause of cancer-related mortality in patients with gastric cancer. Ursolic acid, a pentacyclic triterpenoid compound derived from medicinal herbs, has been demonstrated to exert anticancer effects in various cancer cell systems. However, to the best of our knowledge, the inhibitory effect of ursolic acid on the invasive phenotype of gastric cancer cells has yet to be repor...

Journal: :Biological & pharmaceutical bulletin 2012
Young-Hoon Song Soo-Jin Jeong Hee-Young Kwon Bonglee Kim Sung-Hoon Kim Dong-Youl Yoo

Although ursolic acid isolated from Oldenlandia diffusa (Rubiaceae) was known to have anticancer activities in prostate, breast and liver cancers, the underlying mechanism of ursolic acid in ovarian cancer cells was not investigated so far. In the present study, the apoptotic mechanism of ursolic acid was elucidated in SK-OV-3 ovarian cancer cells by 2,3-bis(2-methoxy-4-nitro-5-sulphophenyl)-2H...

Journal: :Molecular cancer research : MCR 2013
Jacob J Junco Anna Mancha Gunjan Malik Sung-Jen Wei Dae Joon Kim Huiyun Liang Thomas J Slaga

UNLABELLED Ursolic acid, present in apples, rosemary, and other sources, is known to inhibit tumor formation and tumor cell viability in multiple systems, including skin. However, various cancers are resistant to ursolic acid treatment. Herein, skin carcinoma cells (Ca3/7) as compared with skin papilloma cells (MT1/2) displayed more resistance to ursolic acid-induced cytotoxicity. Interestingly...

2012
Steven D. Kunkel Christopher J. Elmore Kale S. Bongers Scott M. Ebert Daniel K. Fox Michael C. Dyle Steven A. Bullard Christopher M. Adams

Skeletal muscle Akt activity stimulates muscle growth and imparts resistance to obesity, glucose intolerance and fatty liver disease. We recently found that ursolic acid increases skeletal muscle Akt activity and stimulates muscle growth in non-obese mice. Here, we tested the hypothesis that ursolic acid might increase skeletal muscle Akt activity in a mouse model of diet-induced obesity. We st...

2003
Shishir Shishodia Sekhar Majumdar Sanjeev Banerjee Bharat B. Aggarwal

The process of tumorigenesis requires cellular transformation, hyperproliferation, invasion, angiogenesis, and metastasis. Several genes that mediate these processes are regulated by the transcription factor nuclear factorB (NFB). The latter is activated by various carcinogens, inflammatory agents, and tumor promoters. Thus, agents that can suppress NFB activation have the potential to suppress...

Journal: :Pharmacological reports : PR 2013
Ji-Hyuk Park Hee-Young Kwon Eun Jung Sohn Kyung A Kim Bonglee Kim Soo-Jin Jeong Jun Ho Song Jin Suk Koo Sung-Hoon Kim

BACKGROUND Ursolic acid, a pentacyclic triterpenoid, is known to exert antitumor activity in breast, lung, liver and colon cancers. Nonetheless, the underlying mechanism of ursolic acid in prostate cancer cells still remains unclear. To investigate the antitumor mechanism, the apoptotic mechanism of ursolic acid via Wnt/β-catenin signaling was examined in PC-3 prostate cancer cells. METHODS C...

Journal: :Molecules 2016
Chao-Min Wang Yun-Lian Jhan Shang-Jie Tsai Chang-Hung Chou

(1) BACKGROUND: Several triterpenoids were found to act synergistically with classes of antibiotic, indicating that plant-derived chemicals have potential to be used as therapeutics to enhance the activity of antibiotics against multidrug-resistant pathogens. However, the mode of action of triterpenoids against bacterial pathogens remains unclear. The objective of this study is to evaluate the ...

2014
Satoshi Mitsuda Tomonobu Yokomichi Junpei Yokoigawa Takao Kataoka

Ursolic acid (3β-hydroxy-urs-12-en-28-oic acid) is a natural pentacyclic triterpenoid that is present in many plants, including medicinal herbs, and foods. Ursolic acid was initially identified as an inhibitor of the expression of intercellular adhesion molecule-1 (ICAM-1) in response to interleukin-1α (IL-1α). We report here a novel biological activity: ursolic acid inhibits intracellular traf...

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