AIMS This population pharmacokinetic analysis was conducted to describe quantitatively the regional differences and sources of interpatient variability on the apparent oral clearance of alisertib. METHODS A population pharmacokinetic analysis was performed on data from 671 cancer patients in Western countries and in Japan/East Asia to whom alisertib 5-150 mg once or twice daily (b.i.d.) was a...

Today, there is general agreement among medical professionals that the use of evidence-based medicine is the standard of care when providing medical services, including in child and adolescent psychiatry. Clinical practice should be based on the best available scientific research. Thus, sharing of scientific reports is a critical aspect for proving quality mental health care to children and ado...

OBJECTIVE To assess changes in insulin resistance and β-cell function in a multiethnic cohort of women in Oslo, Norway, from early to 28 weeks' gestation and 3 months post partum and relate the findings to gestational diabetes mellitus (GDM). METHOD Population-based cohort study of 695 healthy pregnant women from Western Europe (41%), South Asia (25%), Middle East (15%), East Asia (6%) and el...

OBJECTIVES In Western countries, lower socioeconomic status is associated with a higher risk of cardiovascular disease (CVD) and premature mortality. These associations may plausibly differ in Asian populations, but data are scarce and direct comparisons between the two regions are lacking. We, thus, aimed to compare such associations between Asian and Western populations in a large collaborati...

Current data of world oil demand. This includes international bunkers and refinery fuel. Updated on a monthly basis. demand from counties such as Canada, the United States America, Japan, OECD Europe, Belgium, France, Germany, Italy, Netherlands, Spain, Sweden, Kingdom, Australia, Mexico, Republic Korea, Turkey. for crude refined product stocks in Chile, (Western Hemisphere), Kingdom Other Euro...

1 Cynthia Beath was the accepting Senior Editor for this article. 2 We are indebted to the following people for their contributions to WD’s vigilant information systems, for managing the dashboard project, and for the contributions to this paper: John Coyne, Senior Vice President, Worldwide Operations; Chee Pang Sin, Director of Information Technology, Western Digital; Asia; Tom McDorman, Vice ...

ORIGIN AND HISTORY The pistachio is native to western Asia and Asia Minor, where it is still found growing wild in numerous hot, dry locations in Lebanon, Palestine, Syria, Iran, Iraq, India, Southern Europe and the desert countries of Asia and Africa. It was introduced to Europe at the beginning of the Christian era. The first pistachio introductions to the United States were by the USDA plant...

adequate nutrition is essential in early childhood to ensure healthy growth, proper organ formation and function, a strong immune system, and neurological and cognitive development. child malnutrition – as measured by poor child growth – is an important indicator for monitoring population nutritional status and health. in 2013, about 17%, or 98 million children under five years of age in develo...

Although not shown in trials, high performance skill seems to be even more important in super-agers than in younger patients because of increased risks in terms of extension of procedural duration and the consequences of severe adverse events. Gastric cancer is one of the leading causes of cancerrelated mortality worldwide. The incidence is lower in most of the Western countries, like the Unite...