in the rare hereditary bone disorder of osteopetrosis, reduced bone resorption function leads to both the development of densely sclerotic fragile bones and progressive obliteration of the marrow spaces and cranial foramina. marrow obliteration, typically associated with extramedullary hemopoiesis and hepatosplenomegaly, results in anemia and thrombocytopenia and nerve entrapment accounts for p...

Although it is known that replication stress causes genetic instability, the underlying mechanisms are not yet fully understood. A new study by Barlow et al (2013) used an elegant genome-wide chromatin immunoprecipitation approach to reveal that DNA lesions induced by replication stress occur predominantly in early replicating and actively transcribed gene clusters. These ‘early replication fra...

In this paper an image authentication algorithm is proposed where the modified areas in an image are detected, besides an aproximation of the original image, called digest image Cdig, is recovered (recovery capability). Two different watermarks are used. One semi-fragile watermark w1 is used for authentication phase. The digest image Cdig is compressed using an arithmetic code, then redundancy ...

Codium fragile and Chondrus crispus are, respectively, green and red seaweeds which are abundant along the North Atlantic coasts. We investigated the chemical composition and antiviral activity of enzymatic extracts of C. fragile (CF) and C. crispus (CC). On a dry weight basis, CF consisted of 11% protein, 31% neutral sugars, 0.8% sulfate, 0.6% uronic acids, and 49% ash, while CC contained 27% ...

This paper focuses on the non-fragile guaranteed cost control problem for a class of T-S fuzzy time-varying delay systems with local bilinear models. The objective is to design a non-fragile guaranteed cost state feedback controller via the parallel distributed compensation (PDC) approach such that the closed-loop system is delay-dependent asymptotically stable and the closed-loop performance i...