Purpose: To gain insight into the mechanisms of analgesic and anti-inflammatory activities of the root extract of Polygala tenuifolia. Methods: Polygala tenuifolia was extracted with 70 % methanol and tested for analgesic and antiinflammatory activities (0.1, 1, 10 and 100 mg/kg) using the following models: acetic acid-induced writhing, rat paw edema, bradykinin inhibtion with rat ileum, and pr...

BACKGROUND Selaginella convoluta (Arn.) Spring (Selaginellaceae), commonly known as "jericó", is a medicinal plant found in northeastern Brazil. S. convoluta is used in folk medicine as an antidepressant, aphrodisiac, diuretic, analgesic, anti-inflammatory and it is used to combat amenorrhea, coughing and bleeding. This study was performed to evaluate the antinociceptive effects of ethanolic ex...

INTRODUCTION Pain is a very well-known signal of ill health and analgesics are the drugs that are used to relieve pain. The main problem with these drugs remains that of side effects. Safer alternatives are natural herbs. Guduchi (Tinospora cordifolia) is one such plant with analgesic potential but few studies are there. OBJECTIVE To evaluate the analgesic activity of commercially available e...

We have investigated the antinociceptive effects of the essential oil of Ocimum gratissimum L. (Labiatae) (EOOG) in two classical models of pain in male Swiss mice (25-35 g), the writhing test and the formalin test. At doses of 30, 100 and 300 mg/kg (po), EOOG produced a dose-dependent inhibition (from 58.3 4.4 to 40.7 6.3, 36.4 3.6 and 24.6 3.6, respectively; N = 8-10, P<0.05) of aceti...

BACKGROUND Ethnopharmacological approach has explored several leads from plant sources to identify potential new drugs for various diseases including pain. Vanda roxburghii R. Br., an epiphytic orchid is widely distributed throughout Bangladesh. The root of this plant has a folkloric reputation to treat inflammations, fever, dyspepsia, bronchitis, hiccough, piles, snake bites, and diseases of t...

OBJECTIVE The present study was undertaken to evaluate the possible analgesic, neuropharmacological, anti-diarrheal, and cytotoxic activities of the ethanol extract of leaves of Solanum sisymbriifolium Lam. (Family: Solanaceae). MATERIALS AND METHODS The analgesic activity was measured by acetic acid-induced writhing inhibition test. The neuropharmacological activities were evaluated using ho...

Synadenium umbellatum Pax., popularly known in Brazil as "cola-nota," "avelós," "cancerola," and "milagrosa", is a plant species used in folk medicine for the treatment of inflammation, pain, and several diseases. This study aimed to investigate the antinociceptive and anti-inflammatory activities of the ethanolic extract from Synadenium umbellatum Pax. leaves (EES) and its hexane (HF), chlorof...

In folk medicine, Polyalthia suberosa is used as abortifacient, laxative, febrifuge analgesic, filler of tooth cavities, and anti-HIV drug and for rheumatism and various skin infections. The present study was directed to evaluate the analgesic and anti-inflammatory activities of diethyl ether and n-hexane extracts of Polyalthia suberosa leaves (PSDE and PSNH). A variety of tests including forma...

present study reports analgesic activity of petroleum ether, chloroform, ethyl acetate and methanolic extracts of leaves and seeds of trigonella foenum-graecum linn. (fabaceae) using hot plate method for evaluation of central analgesic activity and acetic acid induced writhing test for evaluation of peripheral analgesic activity in mice.   all the extracts of trigonella foenum-graecum showed si...