background: chronic inflammation and dys-regulation of the immune system mechanisms are now well established as primary triggers of gastric cancer and peptic ulcer disease. galectin-9 (gal-9) is a member of the galectin family and known as an inducer of cell aggregation, adhesion and apoptosis. gal-9 interaction with its main ligand t-cell immunoglobulin and mucin domain protein-3 (tim-3) leads...

differentiating sepsis from other noninfectious causes of systemic inflammation is often difficult in the elderly. the aim of this study was to evaluate the ability of c-reactive protein (crp), erythrocyte sedimentation rate (esr), procalcitonin (pct), and interleukin-6 (il-6) to identify elderly patients with sepsis. in this single center prospective observational study, we included all consec...

abstract   background: cosmetic rhinoplasty is now carried out increasingly in an attempt to solve the psychological and social problems of people who are discontent with their nose. little is known about either the psychological status of persons who seek rhinoplasty or potential psychological changes following surgery. the challenge that faces surgeons, is how to identify, before surgical int...

addition of n-butyl nitrite to isolated rat hepatocytes caused an immediate glutathione depletion followed by an inhibition of mitochondrial respiration, inhi- bition of glycolysis and atp depletion. at cytotoxic butyl nitrite concentrations, lipid  peroxidation  occurred  before  the  plasma  membrane  was  disrupted. cytochrome p-450 inhibitors inhibited peroxynitrite formation and prevented ...

human t-cell lymphotropic virus type 1 (htlv-1) is associated with adult t-cell leukemia/lymphoma (atl) and htlv-1-associated myelopathy/tropical spastic paraparesis (ham/tsp). only a limited percentage of infected individuals develop disease in response to the virus while the majority remain asymptomatic and ham/tsp is the most common clinical manifestation of the virus. ham/tsp is an inflamma...

results at high concentrations (40 and 100 μm), apoptosis was demonstrated and it was clearly more prominent in hepatocytes exposed to celecoxib loaded liposomes. conclusions our results showed that celecoxib loaded liposomes robustly induced apoptosis, an action that can potentially make it more relevant than the usual form for chemopreventive strategies and also may raise concerns about its t...

in this work the acidity constants of thiamine in water and water-triton x-100 micelle media solutions, at 25 °c, have been determined spectrophotometrically. to evaluate the ph- absorbance data, a resolution based on the combination of soft-and hard-modeling is applied. the acidity constants of all related equilibria are estimated using the whole spectral fitting of the collected data to an es...