Buruli ulcer is an indolent, slowly progressing necrotizing disease of the skin caused by infection with Mycobacterium ulcerans. In the present study, we applied a redesigned technique to a vast panel of M. ulcerans disease isolates and clinical samples originating from multiple African disease foci in order to (i) gain fundamental insights into the population structure and evolutionary history...

Few studies have examined interactions between IT change and organizational change during information systems evolution (ISE). We propose a dynamic model of ISE where change dynamics are captured in four dimensions: planned change, improvised change, organizational change and IT change. This inductively-generated model yields a rich account of ISE and its drivers by integrating the four change ...

OBJECTIVE To evaluate macular morphological parameters measured by spectral domain optical coherence tomography (SD-OCT) as predictive factors of visual outcome in patients with exudative age-related macular degeneration (AMD) treated with ranibizumab. METHODS A retrospective study was conducted on 47 patients diagnosed with exudative AMD and treated with intravitreal ranibizumab for twelve m...

The PVC membrane of an ion-selective electrode (ISE) sensitive to dibasic phosphate ions (HPO4-ISE) has not been optimized for maximum selectivity, sensitivity, and useable ISE lifetime and further work was necessary to improve its performance. Two areas of investigation are reported here: include the parameters for the lipophilicity of the plasticizer compound used and the amount of cyclic pol...

1. We developed an innovative Integrated Supported Employment (ISE) service protocol, which amplifies the effect of the Individual Placement and Support (IPS) model by the addition of workrelated social skills training. 2. Participants in the ISE outperformed those in the IPS and traditional vocational rehabilitation (TVR) with respect to employment rate, job tenure, and some psychological outc...

In this manual, we describe the software package ISE (acronym for Integrated Search Environment), a tool that implements hierarchical searches with meta-control. ISE actually is a collection of problem-independent routines to support search processes. Mainly, these routines are core routines for solving a search problem and they handle the control of searches and maintain the statistics related...