Previous work indicates that sympathetic nerves participate in the vascular responses to direct cooling of the skin in humans. We evaluated this hypothesis further in a four-part series by measuring changes in cutaneous vascular conductance (CVC) from forearm skin locally cooled from 34 to 29 degrees C for 30 min. In part 1, bretylium tosylate reversed the initial vasoconstriction (-14 +/- 6.6%...

BACKGROUND Local anaesthetics affect blood vessels in various ways, depending upon the site of action and the drug used. There is controversy over the vascular effects of two widely used topical local anaesthetic agents, EMLA and Ametop. We used the transient hyperaemic response (THR) to the brief compression of the brachial artery to assess vascular reactivity of forearm skin after application...

a number of studies has shown that orally administered sweet-tasting solutions reduce signs of pain during painful procedures. the local anesthetic cream emla has recently been shown to be safe for use in neonates. the present study aimed to compare the pain-reducing effect of emla cream with that of orally administered glucose during venipuncturing in newborns in yazd city. a randomized, contr...

BACKGROUND Needle-related procedures (venipuncture, intravenous cannulation) are the most common source of pain and distress for children. Reducing needle related pain and anxiety could be important in order to prevent further distress, especially for children needing multiple hospital admissions. The aim of the present open randomized controlled trial was to investigate the efficacy of adding ...

BACKGROUND Premature infants, who have to spend the first week of their lives in neonatal intensive care units (NICUs), experience pain and stress in numerous cases, and they are exposed to many invasive interventions. The studies have shown that uncontrolled pain experienced during early life has negative and long-term side effects, such as distress, and such experiences negatively affect the ...

25 Temporary deafferentation of the upper limb, with ischemic or anesthetic nerve block, has 26 rapid effects on sensorimotor cortex. Cutaneous anesthesia of the forearm has recently been 27 found to improve sensory and motor function of the paretic hand in chronic stroke patients. 28 However, the neurophysiological mechanisms are unknown. The aim of this study was to 29 investigate the behavio...

eutectic mixture of lidocaine and prilocaine (EMLA cream): comparison with placebo cream and no local premedication. Acta Anaesthesiol Scand 1987;31: 735-9. 8 Hallen B, Olsson GL, Uppfeldt A. Pain-free venepuncture. Effect of timing of application of local anaesthetic cream. Anaesthesia 1984;39:%9-72. 9 Hopkins CS, Buckley CJ, Bush GH. Pain-free injection in infants. Use of a lignocaine-priloca...

OBJECTIVES To measure colloid osmotic pressure in interstitial fluid (COP(i)) from human subcutaneous tissue with the modified wick technique in order to determine influence of topical application of anaesthetics, dry vs. wet wick and implantation time on COP(i). MATERIAL AND METHODS In 50 healthy volunteers interstitial fluid (IF) was collected by subcutaneous implantation of multi-filamento...

OBJECTIVE Circumcision is a commonly performed surgical procedure but choice of anesthesia remained an issue of research and debate. This study was conducted to find out the effectiveness of the eutectic mixture of local anesthetic (EMLA) cream with dorsal penile nerve block (DPNB) using lignocaine, for reduction of pain during circumcision. METHODOLOGY This was comparative study carried out ...