BACKGROUND Sepsis is a common and frequently fatal condition. Human recombinant activated protein C (APC) has been used to reduce the high rate of death by severe sepsis or septic shock. This is an update of a Cochrane review (originally published in 2007 and updated in 2008). OBJECTIVES We assessed the clinical effectiveness and safety of APC for the treatment of patients with severe sepsis ...

We analyze multi-band photometry of a subsample of low mass stars in the associations Ori OB1a and 1b discovered during the CIDA Orion Variability Survey, which have ages of 7 10 Myr and 3 5 Myr, respectively. We obtained UBV RcIc photometry at Mt Hopkins for 6 Classical T Tauri stars (CTTS) and 26 Weak T Tauri stars (WTTS) in Ori OB1a, and for 21 CTTS and 2 WTTS in Ori OB1b. We also obtained L...

The factors governing neuronal loss in Parkinson’s disease (PD) are the subject of continuing speculation and experimental study. In recent years, factors that act on most or all cell types (pan-cellular factors), particularly genetic mutations and environmental toxins, have dominated public discussions of disease aetiology. Although there is compelling evidence supporting an association betwee...

Purpose: Nonmelanoma skin cancer incidence is enhanced >50-fold in patients taking antirejection drugs (ARD) following organ transplantation. Preclinical studies suggest that ARD treatment increases transforming growth factor-β1 (TGF-β1) levels, which contribute to enhanced tumor susceptibility independent of the immunosuppressive effects of ARDs. This study investigates whether TGF-β signaling...

We present results of a large scale, multi-epoch optical survey of the Ori OB1 association, carried out with the QuEST camera at the Venezuela National Astronomical Observatory. We identify for the first time the widely spread low-mass, young population in the Orion OB1a and OB1b sub-associations. Candidate members were picked up by their variability in the V -band and position in color-magnitu...

We present spectra taken with the Infrared Spectrograph on Spitzer covering the 5−38μm region of the ten Ultraluminous Infrared Galaxies (ULIRGs) found in the IRAS Bright Galaxy Sample. Among the BGS ULIRGs, we find a factor of 50 spread in the spectral slope from 5.5−60μm in the rest frame. There is evidence for water ice and hydrocarbon absorption (from 5.5−6.5μm) in 7/10 BGS ULIRGs, as well ...

While the influence of HLA-AB and -DRB1 matching on the outcome of bone marrow transplantation (BMT) with unrelated donors is clear, the evaluation of HLA-C has been hampered by its poor serological definition. Because the low resolution of standard HLA-C typing could explain the significant number of positive cytotoxic T lymphocyte precursor frequency (CTLpf) tests found among HLA-AB-subtype, ...