Please see related Short report: https://pssjournal.biomedcentral.com/articles/10.1186/s13037-017-0125-1.

Background The RAS/MAPK pathway has emerged as a critical for therapeutic targeting in spectrum of solid tumor and hematological malignances. Inhibitors MAPK targets, such RAS, BRAF, or MEK have been approved the treatment cancer either monotherapy combination. However, there no drug ERK1/2, terminal kinases Ras-Raf-MEK-ERK signal transduction cascade. combination ERK1/2 inhibitor checkpoint in...

PURPOSE: This study investigated whether physical activity (PA) and cardiorespiratory fitness (CRF) modulate the relationship between eating speed metabolic syndrome (MetS) in Korean university students.METHODS: A total of 1,071 college students 751 males 320 females participated this study. The volume PA (minutes per week) assessed by a self-reported questionnaire was classified as sufficient ...

A Correction to this paper has been published: 10.1007/s00222-017-0749-x

The aryl hydrocarbon receptor (AhR) is a ligand-dependent, basic helix-loop-helix Per-ARNTSim (PAS) containing transcription factor that can bind and be activated by structurally diverse chemicals, including the toxic environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). As no experimentally determined structures of the AhR ligand binding domain (LBD) are available and previous ...

The knowledge of Iranian vernacular structures is based on geometry, and there is a possibility of recreating such structural patterns aimed at producing movable structures. The purpose of this research was to utilize the patterns of vernacular structures to provide a lightweight structural model. The questions raised included how to create various forms based on the structural history of any r...

An error occurred during the publication of a number of articles in BMC Palliative Care. These articles were erroneously published in volume number 17, which is listed with a publication date of 2018. However, these articles were published in final form in the year 2017. Provided below are the actual publication dates and the correct citation for each affected article. Please note that the cita...

Background Emotional disorders (EDs) are among the most prevalent mental disorders. Existing evidence-based psychological treatments not sufficient to reduce disease burden of It is therefore essential implement innovative solutions achieve a successful dissemination treatment protocols, and in this regard, use information communication technologies such as internet can be very useful. Furtherm...