Objective: Mangiferin (MGF) is a natural xanthone, with regulation effect on lipid metabolism. However, the molecular mechanism remains unclear. We purposed after oral administration, MGF is converted to its active metabolite(s), which contributes to the effects on lipid metabolism. Methods: KK-Ay mice were used to validate the effects of MGF on lipid metabolic disorders. Liver biochemical indi...

background: transforming growth factor-β1 (tgf-β1) has been found to play a crucial role in early central nervous system development. several studies have illustrated decreased tgf-β1 levels in sera and brains of autistic children. two point mutations in the tgf-β1 signal peptide at 869t/c and 915g/c have been reported to influence tgf-β1 expression. the aim of the present study was to investig...

to determine the optimum weed management method and plant population density on chickpea yield, a split plot experiment based on rcbd with four replications was carried out at the university of tehran research farm (located in karaj) during 2010-2011. the main factor consisted of nine treatments including: 1. trifluralin pre-plant, 2. pendimethalin pre-plant, 3. complete weeding, 4. imazethapyr...

Skeletal muscle stem (satellite) cells supporting growth/regeneration are thought to be activated and incorporated into growing myofibers by both endocrine and locally expressed autocrine/paracrine growth factors, the latter being load sensitive. We recently found that myofiber hypertrophy with resistance training is superior in young men (YM) vs. young women and older adults (Kosek DJ, Kim JS,...

Diamond-Blackfan anemia (DBA) is a congenital hypoplastic anemia characterized by decreased erythroid progenitors in the marrow. Human DBA in some ways resembles the anemia of SI and Wmutant mice, which respectively result from defects of the genes encoding mast/stem cell growth factor (Mgf) and its tyrosine kinase receptor (Kit).’ However, we previously noted that humans with pathologic mutati...

Mutations of the receptor tyrosine kinase, Kit, or its ligand, mast growth factor (Mgf), affect three unrelated cell populations: melanocytes, germ cells, and mast cells. Kit signaling is required initially to prevent cell death in these lineages both in vitro and in vivo. Mgf appears to play a role in the survival of some hematopoietic cells in vitro by modulating the activity of p53. Signalin...

Diabetes mellitus induces a reduction in skeletal muscle mass and strength. Strength training is prescribed as part of treatment since it improves glycemic control and promotes increase of skeletal muscle mass. The mechanisms involved in overload-induced muscle hypertrophy elicited at the establishment of the type I diabetic state was investigated in Wistar rats. The purpose was to examine whet...