Many theoretical and practical problems arise at different stages of the design/manufacturing process during development of a pump. The experience obtained in pump development proves that the quality of a pump depends on many factors, which should he satisfied to receive good results. At the same time, the theory of engineering design principles exists, which is applicable to designing various ...

The Pulsatile Catheter (PUCA) pump, a left ventricular assist device, was tested during acute experiments in calves using asynchronous and ECG-synchronous assist modes. The aim of the study is to compare ECG-synchronous and asynchronous assist, and to find the optimal driving mode for the PUCA-pump with respect to left ventricular myocardial oxygen consumption (LV MVO2), pump flow, and coronary...

In pediatric ventricular assist device (VAD) design, the process of matching device characteristics and dimensions to the relevant disease conditions poses a formidable challenge because the disease spectrum is more highly varied than for adult applications. One example arises with single-ventricle congenital defects, which demand palliative surgeries that create elevated systemic venous pressu...

We have studied the mechanism by which metabolic energy is coupled to potassium accumulation by the fermentative bacterium, Streptococcus faecalis. In starving cells, K+ movements into the cells or out are very slow; even 42K+/K+ exchange requires concurrent metabolism of glucose or arginine. Metabolizing cells accumulate K+, establishing a concentration gradient of some 50,000. Accumulation is...

Children born with univentricular heart disease typically must undergo three open heart surgeries within the first 2-3 years of life to eventually establish the Fontan circulation. In that case the single working ventricle pumps oxygenated blood to the body and blood returns to the lungs flowing passively through the Total Cavopulmonary Connection (TCPC) rather than being actively pumped by a s...

Yohannes T. Ghebremariam, Paea LePendu, Jerry C. Lee, Daniel A. Erlanson, Anna Slaviero, Nigam ADMA An Unexpected Effect of Proton Pump Inhibitors: Elevation of the Cardiovascular Risk Factor Print ISSN: 0009-7322. Online ISSN: 1524-4539 Copyright © 2013 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231...

We explore the impact of a latitudinal shift in the westerly wind belt over the Southern Ocean on the Atlantic meridional overturning circulation (AMOC) and on the carbon cycle for Last Glacial Maximum background conditions using a state-of-the-art ocean general circulation model. We find that a southward (northward) shift in the westerly winds leads to an intensification (weakening) of no more...

The paper analyses the effect of electrohydrodynamic (EHD) pumping on the control of natural circulation loops (NCLs). The two major objectives of the investigation are: finding the optimal configuration of an EHD pump and demonstrating that the NCL flow direction can be inverted by exploiting the EHD phenomena. In the initial experimental set-up, we measured the static pressure rise given by a...

Twin reversed arterial perfusion (TRAP) syndrome is a rare condition (0.3:10,000 births) that occurs in monochorionic twin pregnancies, resulting in coexistence of a normal "pump" twin and an acardiac twin. The acardiac twin is dependent upon the normal twin to provide circulation by means of vascular anastomosis. Many of the bizarre defects are felt to be caused by low oxygen tension and this ...