نتایج جستجو برای: active site concentration
تعداد نتایج: 1100816 فیلتر نتایج به سال:
1. The authors use a polyexponential equation (equation 1) to describe the time course of the plasma concentrations of a drug in lieu of a compartmental interpretation suggested by Sheiner et al. As a consequence, the effect compartment can now contain any amount of a drug and is not limited to being “negligibly small” as postulated by Sheiner et al. 2. Sheiner et al. introduced keo as the firs...
Design of selective cyclooxygenase-2 (COX-2) inhibitors is still a challenging task because of active site similarities between COX isoenzymes. To help with this issue, we tried to generate a 3D-QSAR (3 dimensional quantitative structure activity relationship) model that might reflect the essential features of COX-2 active sites. Compounds in a series of resveratrol derivatives inhibitors with ...
HCV-induced hepatitis is one of the most debilitating diseases. The limited number of anti-HCV drugs and drug-resistance necessitate developing of new scaffolds with different mode of actions. HCV non-structural protein 5B (NS5B) is an attractive target for development of novel inhibitors of HCV replication. In this paper, new N'-arylidene-6-(benzyloxy)-4-oxo-1,4-dihydroquinoline-3-carbohydrazi...
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